Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results also indicated that AR cells increased abundantly in Tbx3, a downstream target of Wnt/β-catenin that it is implicated in liver cancer.
|
24317053 |
2013 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Altogether, our study uncovers a regulatory mechanism underlying liver cancer-specific Wnt transcriptional output, and suggests that TRIB2 functions as a signaling nexus to integrate the Wnt/β-catenin, Hippo/YAP, and C/EBPα pathways in cancer cells.
|
23769673 |
2013 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
BrMC can inhibit the functions and characteristics of LCSCs derived from the liver cancer MHCC97 cell line through downregulation of β-catenin expression.
|
24431896 |
2013 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The Wnt-pathway was assessed using mRNA (642 HCCs and 21 liver cancer cell lines) and miRNA expression data (89 HCCs), immunohistochemistry (108 HCCs), and CTNNB1-mutation data (91 HCCs).
|
22811581 |
2012 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also investigated beta-catenin pathway activation in two liver cancer cell lines, HuH-6 and HuH-7.
|
21992464 |
2011 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine the importance of CCND1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesis, we investigated the genetic interactions between CCND1, beta-catenin, and c-Met in liver cancer development using mouse models.
|
19118010 |
2009 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We frequently detected the active form of beta-catenin and accumulation of nuclear beta-catenin in liver cancer cell lines.
|
18592156 |
2008 |
Adult Liver Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study confirms that beta-catenin deregulation is involved in sporadic hepatoblastoma and also suggests that mismatch repair defects and p53 mutations contribute to this rare liver cancer.
|
17962810 |
2008 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, we identified a number of candidate Wnt/beta-catenin target genes that can be useful for studying the role of altered Wnt signaling in liver cancer development, and showed that some of them might be direct targets of Wnt signaling in hepatoma cells.
|
17157329 |
2007 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer.
|
17283120 |
2007 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer.
|
17030191 |
2006 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Wnt/beta-catenin activation is observed in normal liver development, regeneration, and liver cancer.
|
16012954 |
2005 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the EBP50/beta-catenin complex promotes Wnt signaling, and over-expression of EBP50 may work cooperatively with beta-catenin in the development of liver cancer.
|
12830000 |
2003 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry showed that all normal liver tissues and para-cancerous tissues examined showed membranous-type staining for beta-catenin protein, frequently with weak expression in the cytoplasm, but no beta-catenin accumulation in nuclei was found; while in liver cancer, 21 cases (61.8%) of HCC examined showed accumulated type in cytoplasms or nuclei.
|
11570580 |
2001 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of the current investigation was to define the prevalence of genetic alterations in p16 and beta-catenin in NNK-induced rat liver cancer to determine if the molecular mechanisms seen in human tumors are the same in this animal model.
|
11238187 |
2001 |