|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Increased cytoplasmic and/or nuclear beta-catenin staining was seen in 94% and 80% of the adenomas. beta-Catenin nuclear staining was strongly associated with MYC levels (p value 0.03) but not with KRAS mutations.Copy number aberrations were rare.
|
20196079 |
2010 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In conclusion, the molecular and pathological classification of hepatocellular adenomas permits the identification of strong genotype-phenotype correlations and suggests that adenomas with beta-catenin activation have a higher risk of malignant transformation.
|
16496320 |
2006 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
No mutations or deletions were seen in exon 3 of the beta-catenin gene for either the adenomas or the carcinoma.
|
18246041 |
2008 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Consistent with the presence of WNT pathway gene alterations, all superficially serrated adenomas showed focal or diffuse nuclear β-catenin accumulation.
|
29789649 |
2018 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In non-ampullary lesions, abnormal nuclear localization of β-catenin was observed in 21 (84.0%) of 25 adenomas and 4 (33.3%) of 12 adenocarcinomas.
|
28467793 |
2017 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Furthermore, aberrant β-catenin staining co-localized with DR4 and DR5 expression in 92% of adenomas.
|
24379239 |
2014 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In mice with heterozygous disruption of Apc(APC(Δ1638/+)), Smad4-deficient intestinal adenomas had increased levels of β-catenin mRNA and expression of Wnt target genes compared with adenomas from APC(Δ1638/+) mice that expressed Smad4.
|
22115830 |
2012 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
The clinical, pathological, and immunophenotypic (hMLH1, hMSH2, MGMT, MIB-1, p53, and beta-catenin) properties of 28 mixed hyperplastic and adenomatous polyps of the colon (7 of which also contained carcinoma within the same lesion) were evaluated for the above immunopeptides in each of the different morphologic areas of the polyps, and the results were compared to traditional hyperplastic polyps, serrated adenomas, and conventional (nonserrated) adenomas.
|
15712188 |
2005 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Adenomas and carcinomas showing both nuclear and reduced membranous expression of beta-catenin, compared with those with normal membranous expression, tended to show allele loss ( P<0.01).
|
11956815 |
2002 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In the context of APC (adenomatous polyposis coli) deficiency (Apc(Min/+) mice), loss of Fbxw7 accelerated intestinal tumorigenesis and death and promoted accumulation of β-catenin in adenomas at late but not early time points.
|
21282377 |
2011 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Similar to sporadic CRC, CTNNB1 was frequently activated at the adenoma stage, and TP53 mutation occurred during cancer development from adenoma.
|
27563825 |
2016 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
It occurred at the transition to dysplasia in serrated polyps with a significant increase in nuclear β-catenin labeling from sessile serrated adenomas (10%) to sessile serrated adenomas with dysplasia (55%) and traditional serrated adenomas (9%) to traditional serrated adenomas with dysplasia (39%) (P=0.0001).
|
29148535 |
2018 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We report a case of a well-differentiated hepatocellular neoplasm with Dubin-Johnson-like pigment displaying histological features overlapping with a beta-catenin mutated inflammatory adenoma and a well-differentiated hepatocellular carcinoma in a non-cirrhotic liver.
|
26663015 |
2015 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
β-Catenin stained the cell membrane, cytoplasm, and nuclei of the adenoma.
|
25449630 |
2015 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Four APAs showed a predominant (≥50%) zona fasciculata-like cell pattern: one tumor had CYP11B1 H-score = 150, no detectable CYP11B2 expression, and harbored a PRKACA p.Leu206Arg mutation (that we have reported previously elsewhere), one had no CYP11B1 expression, CYP11B2 H-score = 40, and no mutations; the remaining two adenomas had high CYP11B1 H-score (160 and 240, respectively) and low CYP11B2 H-score (30 and 15, respectively), with the latter harboring a CTNNB1 p.Ser45Phe activating mutation.
|
28405879 |
2017 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Immunohistochemical analysis of adenomas revealed increased nuclear beta-catenin accumulation in adenomas from Rassf1a(-/-); Apc(+/Min) mice, compared to those from Rassf1a(+/+); Apc(+/Min) mice, but no differences in proliferation marker (Ki67) staining patterns.
|
18391979 |
2008 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Sequencing analyses identified APC or CTNNB1 mutations in the majority of sporadic adenomas (58/84, 69%) and MMR-proficient Lynch syndrome-associated adenomas (13/18, 72%).
|
28548127 |
2017 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Expression profiling revealed that ISC signatures, as well as the Wnt/β-catenin and Notch signaling pathways are downregulated in Ap4-deficient adenomas and intestinal organoids.
|
30177706 |
2018 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The lower apoptotic activity of low-grade slightly elevated adenomas can be partly attributed to upregulated β-catenin pathway activity and downregulated c-Myc expression.
|
28533663 |
2017 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Somatic mutations of β-catenin and PRKACA are observed in non secreting or cortisol producing adenomas, respectively.
|
26038203 |
2015 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Here, we focused our investigation on the beta-catenin gene which is implicated in colorectal carcinogenesis and tested whether beta-catenin mRNA is detectable in the plasma of colorectal carcinoma and adenoma patients using quantitative reverse transcriptase-PCR.
|
15014011 |
2004 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
We corroborated the Wnt/APC signalling pathway on the NT1 receptor promoter activation with human colon carcinogenesis, and showed that NT1 receptor gene activation was perfectly correlated with nuclear or cytoplasmic beta-catenin localization while NT1 receptor was absent when beta-catenin was localized at the cell-cell junction in early adenomas of patients with familial adenomatous polyposis, hereditary non-polyposis colorectal cancer and loss of heterozygosity tumours.
|
16299383 |
2006 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis.
|
11522744 |
2001 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
BRAF and beta-catenin mutations were detected in 3 and 8% of the 101 flat-type adenomas, respectively.
|
17143260 |
2007 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Activation of β-catenin and ERK1/2 was mitigated in Apc(Min/+);Nherf2(-/-) adenomas.
|
26867566 |
2016 |