Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We applied this method for five biomarkers (CDX2, SOX2, SOX9, E-cadherin, and β-catenin) using tissue microarrays of a Norwegian unselected series of primary colorectal cancer.
|
31641225 |
2020 |
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
TIPE1 Impairs Stemness Maintenance in Colorectal Cancer Through Directly Targeting β-catenin.
|
31111874 |
2020 |
Colorectal Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
<b>Abbreviations</b>: ACTB: actin beta; ATG5: autophagy related 5; ATG12: autophagy related 12; CQ: chloroquine; CRC: colorectal cancer; CTNNB1: catenin beta 1; EBSS: Earle's balanced salt solution; KO: knockout; LAMP1: lysosomal associated membrane protein 1; LAMP2: lysosomal associated membrane protein 2; MAP1LC3: microtubule associated protein 1 light chain 3; MKI67: marker of proliferation Ki-67; mRNA: messenger RNA; PX: phox homology; RT-qPCR: real time quantitative polymerase chain reaction; siRNA: small interfering RNA; SNX10: sorting nexin 10; SQSTM1: sequestosome 1; SRC: SRC proto-oncogene, non-receptor tyrosine kinase; STAT3: signal transducer and activator of transcription 3; WT: wild type.
|
31208298 |
2020 |
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Of functional importance, disruption of CDCP1 reduces nuclear localized, chromatin-associated β-catenin and nuclear localized E-cadherin, increases sequestration of these proteins in cell membranes, disrupts regulation of CRC promoting genes, and reduces CRC tumor burden.
|
31471585 |
2020 |
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Meanwhile, we reported a negative correlation between miR-150 and β-catenin in colorectal cancer.
|
31731194 |
2020 |
Colorectal Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Four of 10 CRCs with the alterated/mutant β-catenin staining pattern studied in depth, from 181 total CRCs from tissue microarray, had pathogenic CTNNB1 mutations.
|
30177831 |
2019 |
Colorectal Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
(P)RR silencing was performed in human colorectal cancer cells containing constitutive activating mutations in the Wnt/β-catenin pathway.
|
30555158 |
2019 |
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Microsatellite, v-Ki-Ras2 Kristen rat sarcoma viral oncogene homolog (KRAS), v-raf murine sarcoma viral oncogene homolog B1 (BRAF), tumor protein 53 (TP53) and β-catenin status were evaluated and compared between synchronous CRC lesions in each patient.
|
30842178 |
2019 |
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
EGFL6 promotes cell proliferation in colorectal cancer via regulation of the WNT/β-catenin pathway.
|
30693973 |
2019 |
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
In conclusion, the findings provided novel approaches for the identification of β-catenin targets, which may become prognostic biomarkers or drug targets for the management of CRC.
|
31516589 |
2019 |
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
TGM2 interference regulates the angiogenesis and apoptosis of colorectal cancer via Wnt/β-catenin pathway.
|
31010374 |
2019 |
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
In the present study an attempt was made to screen CTNNB1 gene in colorectal cancer samples from Pakistani population and investigated the association of CTNNB1 gene mutations in the development of colorectal cancer.
|
31699039 |
2019 |
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We studied interactions between lysine demethylase 4D (KDM4D or JMJD2D) and β-catenin, a mediator of Wnt signaling, in CRC cell lines and the effects on tumor formation in mice.
|
30472235 |
2019 |
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
LKB1 and YAP phosphorylation play important roles in Celastrol-induced β-catenin degradation in colorectal cancer.
|
31040884 |
2019 |
Colorectal Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The protein level of DKK1, β-catenin and phosphorylated glycogen synthase kinase-3β (pGSK-3β) were analyzed by western blotting. miR-410 was revealed to be upregulated in CRC cell lines.
|
30655833 |
2019 |
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
However, promotion of intestinal tumorigenesis following deletion of PPARD in <i>Apc<sup>min</sup></i> mice has raised questions about the effects of PPARD on aberrant β-catenin activation and colorectal cancer.
|
30679176 |
2019 |
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings showed that miR-182 exerted its oncogenic role in CRC by targeting DAB2IP, which may be involved in activating the PI3K/Akt/mTOR and Wnt/β-catenin pathways, shedding a novel light on the molecular mechanism of CRC tumorigenesis.
|
30974224 |
2019 |
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Furthermore, LDOC1 downregulated the Wnt/β‑catenin pathway in CRC.
|
31002361 |
2019 |
Colorectal Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study aims to determine the contribution of polymorphisms in the genes of the β-catenin destruction complex to develop CRC, specifically adenomatous polyposis coli (APC) (rs11954856 G>T and rs459552 A>T), axis inhibition protein 1 (AXIN1) (rs9921222 C>T and rs1805105 C>T), AXIN2 (rs7224837 A>G), and dishevelled 2 (DVL2) (2074222 G>A and rs222836 C>T).
|
31723073 |
2019 |
Colorectal Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Increased TRIM29 expression positively correlated with lymph node metastasis and β-catenin expression in patient CRC tissues.
|
30813948 |
2019 |
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The importance of upregulated Wnt signaling in colorectal cancers led to efforts to develop inhibitors that target β-catenin in this pathway.
|
31774672 |
2019 |
Colorectal Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
iTRAQ-based proteomic analysis of DMH-induced colorectal cancer in mice reveals the expressions of β-catenin, decorin, septin-7, and S100A10 expression in 53 cases of human hereditary polyposis colorectal cancer.
|
29956073 |
2019 |
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Mechanically, increased expression of miR-92a-3p activates Wnt/β-catenin pathway and inhibits mitochondrial apoptosis by directly inhibiting FBXW7 and MOAP1, contributing to cell stemness, EMT, metastasis and 5-FU/L-OHP resistance in CRC.
|
31064356 |
2019 |
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Meanwhile, the possible relationships between FOXM1 and β-catenin in CRC samples were evaluated using SPSS software, and a significant positive correlation was found (<i>P</i><0.05).
|
31118796 |
2019 |
Colorectal Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Although Wnt/β-catenin and Notch signaling pathway have been known to be closely related to the initiation and development of CRC, the impacts of Aloe vera on these cancerous pathways have not been completely determined yet.
|
31319122 |
2019 |