|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Emodin and AZT synergistically inhibit the proliferation and induce the apoptosis of leukemia K562 cells through the EGR1 and the Wnt/β‑catenin pathway.
|
31746437 |
2020 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the miR-124 mimic obviously upregulated glycogen synthase kinase 3β (GSK-3β) while downregulating β-catenin, T cell transcription factor 4 (TCF-4) and leukemia enhancer factor 1 (LEF-1).
|
30740945 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeting miR-193a-AML1-ETO-β-catenin axis by melatonin suppresses the self-renewal of leukaemia stem cells in leukaemia with t (8;21) translocation.
|
31119862 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Volatile anesthetics sevoflurane targets leukemia stem/progenitor cells via Wnt/β-catenin inhibition.
|
30257344 |
2018 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data indicate that PHB is a direct target of β-catenin and the increased level of PHB in leukemia can be regulated by Wnt signaling.
|
28440457 |
2017 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the expression levels of β-catenin, Ki-67, glycogen synthase kinase 3β (GSK-3β), phosphorylated GSK-3β, T-cell transcription factor 4 (TCF-4), and leukemia enhancer factor 1 (LEF-1) were all markedly upregulated by ANRIL.
|
28251886 |
2017 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results showed that leukemia cell lines (>95 % cells) had increased endogenous levels of β-catenin as compared to mononuclear cells from healthy donors (0 %).
|
27766528 |
2017 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SOX12 may be involved in leukaemia progression by regulating the expression of β-catenin and then interfering with TCF/Wnt pathway, which may be a target for AML.
|
27858992 |
2017 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Suppression of β-catenin by indomethacin or β-catenin shRNA reduced proliferation and survival of human leukemia cell lines with del(5q) but not of control leukemia cell lines <i>in vitro</i>; β-catenin inactivation also inhibited leukemia progression <i>in vivo</i> in xenograft mice reconstituted with del(5q) leukemia cell lines.
|
28611040 |
2017 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inactivation of Wnt antagonists could play an important role in leukemia progression by activating the Wnt/β-catenin pathway.
|
28184923 |
2017 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
First, we present a so far unknown regulation of PON2 protein expression through the Wnt/GSK3β/β-catenin pathway in leukemia and OSCC cells.
|
27322774 |
2016 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alternative RUNX1 Promoter Regulation by Wnt/β-Catenin Signaling in Leukemia Cells and Human Hematopoietic Progenitors.
|
26580584 |
2016 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of γ-catenin mRNA (a close homologue of β-catenin) has also been reported in AML and has been linked to the pathogenesis of this disease, however, the relative roles of these catenins in leukemia remains unclear.
|
22858986 |
2013 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML.
|
22482506 |
2012 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis.
|
21103407 |
2010 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Leukemia cell lines were examined for Wnt pathway inhibitor methylation and total beta-catenin levels, and had frequent methylation of Wnt inhibitors and upregulated beta-catenin by Western blot and immunofluorescence.
|
20795789 |
2010 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our murine model provides a useful platform to study human MDS/AML transformation, as well as the Wnt/beta-catenin pathway's role in the pathogenesis of leukemia stem cells.
|
16763212 |
2006 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
LHGDN |
Anticancer-drug-induced apoptotic cell death in leukemia cells is associated with proteolysis of beta-catenin.
|
12127563 |
2002 |