Mesothelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mesothelioma cell lines with and without β-catenin gene expression were transfected with Dvl-3 siRNA and were cultured with gefitinib, and cell viability, colony formation and cell cycle analyses were performed.
|
29403559 |
2018 |
Mesothelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, overexpression of let 7b using let-7b mimics enhanced the antitumor effect of ursolic acid to attenuate the expression of procaspases 3, pro-PARP, pAKT, β-catenin and Twist and increase sub-G1 accumulation in H2452 mesothelioma cells.
|
28090191 |
2016 |
Mesothelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied 109 malignant mesotheliomas (58 epithelioid, 26 sarcomatoid, and 25 biphasic) by immunohistochemistry and qRT-PCR analysis, and demonstrated a substantial switch from epithelial markers (E-cadherin, β-catenin, and cytokeratins 5/6) to mesenchymal markers (N-cadherin, vimentin, α-smooth muscle actin, Snail, Slug, Twist, ZEB1, ZEB2, S100A4, MMP2, and MMP9) through epithelioid to biphasic and sarcomatoid histotypes.
|
21983934 |
2012 |
Mesothelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The cytoplasmic expression of beta-catenin was observed in 38 of 43 cases of mesothelioma without any nuclear reactivity.
|
20596629 |
2010 |
Mesothelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that methylation silencing of SFRP4 may play an important role in aberrant Wnt activation in mesothelioma even in the absence of beta-catenin.
|
15705870 |
2005 |
Mesothelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we show that blocking Wnt-1 signaling in beta-catenin-deficient mesothelioma cell lines H28 and MS-1 induces apoptotic cell death.
|
15150100 |
2004 |
Mesothelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma.
|
15451431 |
2004 |
Mesothelioma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In conclusion, our data indicate that inactivation of beta-catenin by a 3p21.3 homozygous deletion might be a crucial event in the development of the mesothelioma NCI-H28 cells.
|
12970740 |
2003 |
Mesothelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thirteen of 15 mesotheliomas examined showed consistent overexpression of Dvl and increased cytosolic beta-catenin levels as compared with controls.
|
12907630 |
2003 |
Mesothelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, Northern blot analysis of 26 lung cancer and eight mesothelioma cell line RNAs detected ubiquitous expression of the beta-catenin messages except NCI-H28, although Western blot analysis showed that relatively less amounts of protein products were expressed in some of lung cancer cell lines.
|
11464291 |
2001 |
Mesothelioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Deletion of most beta-catenin coding exons was confirmed in line NCI-H28 (lung mesothelioma) and a silent mutation at codon 214 in exon 5 was found in HeLa (cervical adenocarcinoma).
|
11437403 |
2001 |
Mesothelioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we identified a homozygous deletion of beta-catenin in the mesothelioma, NCI-H28, associated with reduced WNT7a and the lowest overall cell line expression of HOXA1, HOXA7, HOXA9, and HOXA10, whereas HOXB9 levels were unaffected.
|
11070089 |
2000 |