Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mechanistic analysis demonstrated that miR-106a-3p specifically targeted the adenomatous polyposis coli (APC) gene, and LINC01133/miR-106a-3p suppressed the EMT and metastasis by inactivating the Wnt/β-catenin pathway in an APC-dependent manner.
|
30134915 |
2018 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The corresponding hot spot mutations are located in exon 3 of the CTNNB1 gene or alternatively, in the APC tumor suppressor gene, most often as a germline mutation.
|
29705714 |
2018 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
There are at least five mechanisms by which APC can regulate the formation of the β-catenin/TCF complex: This paper presents a computational model for the Wnt pathway that explicitly includes the above five roles of APC in regulating β-catenin/TCF formation.
|
30110600 |
2018 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APC deletion deregulates β-catenin, leads to high Wnt tone, and disrupts Notch1 signaling and primary cilium maintenance necessary for radial progenitor functions.
|
28916710 |
2017 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data establish OLFM4 as a critical negative regulator of the Wnt/β-catenin and NF-κB pathways that inhibits colon-cancer development initiated by APC mutation.
|
26973250 |
2016 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutations of APC and KRAS are frequently observed in human colorectal cancers (CRCs) and the Wnt/β-catenin and Ras pathways are consequently activated in a significant proportion of CRC patients.
|
27470214 |
2016 |
Atrial Premature Complexes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PTEN inactivation by mutation or allelic loss also occurs in CRCs. miR‑135b was reported to be upregulated in CRCs and its overexpression was due to APC/β‑catenin and PTEN/PI3K pathway deregulation.
|
25571954 |
2015 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
APC is best known as a scaffold protein in the β-catenin destruction complex, whose activity is antagonized by canonical Wnt signaling.
|
26193883 |
2015 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Regulation of the phosphorylation and nuclear import and export of β-catenin by APC and its cancer-related truncated form.
|
24496450 |
2014 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
APC is best known for its role as a negative regulator of the Wnt/β -catenin pathway.
|
24200292 |
2014 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
APC participates in a multiprotein "destruction complex" that targets the proto-oncogene β-catenin for ubiquitin-mediated proteolysis; however, the mechanistic role of APC in the destruction complex remains unknown.
|
24931405 |
2014 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
MicroRNA-21 promotes tumour malignancy via increased nuclear translocation of β-catenin and predicts poor outcome in APC-mutated but not in APC-wild-type colorectal cancer.
|
24832083 |
2014 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
FIP200 inhibits β-catenin-mediated transcription by promoting APC-independent β-catenin ubiquitination.
|
22751121 |
2013 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Biallelic inactivation of the Apc tumor suppressor gene via the CDX2P-CreER(T2) transgene in colon epithelium led to acute alterations in cell proliferation, apoptosis, and morphology, along with mitotic spindle misorientation, β-catenin nuclear localization, and induction of the intestinal stem cell markers Lgr5 and Musashi-1 and the Sox9 transcription factor.
|
23769888 |
2013 |
Atrial Premature Complexes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The absent expression of APC had a correlation with the expression of β-catenin (P = 0.000).
|
22741528 |
2012 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show here that binding of beta-catenin to the 15R of APC is necessary and sufficient to target beta-catenin for degradation whereas binding to the 20R1 is neither necessary nor sufficient.
|
19966865 |
2010 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the influence of a major regulatory protein of beta-catenin, the APC tumor suppressor gene, on VDR-dependent inhibition of beta-catenin activity was examined.
|
20043299 |
2010 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Of note, although M3-APC can bind beta-catenin, the G2 arrest did not correlate with beta-catenin expression or activity, similar to what was seen with M2-APC.
|
20368985 |
2010 |
Atrial Premature Complexes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the normal breast, tightly regulated expression of Wnt/beta-catenin pathway components, including Wnts and the APC tumor suppressor, dictates its role in balancing stem cell self-renewal, maintenance and differentiation during embryonic and postnatal development.
|
20545611 |
2010 |
Atrial Premature Complexes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cells harboring mutant APC contain elevated levels of the β-catenin transcription coactivator in the nucleus which leads to abnormal expression of genes controlled by β-catenin/T-cell factor 4 (TCF4) complexes.
|
20460455 |
2010 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in APC causing Gardner's syndrome are clustered in a region encoding a series of amino-acid repeats responsible for the binding to beta-catenin.
|
19573802 |
2009 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of APC and beta-catenin in the aetiology of aggressive fibromatosis (desmoid tumors).
|
18722078 |
2009 |
Atrial Premature Complexes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In truncated APC, the CID is absolutely necessary to down-regulate the transcriptional activity and the level of beta-catenin, even when an axin/conductin binding site is present.
|
18854359 |
2009 |
Atrial Premature Complexes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, the silencing of APC did not alter expression of beta-catenin or the apoptotic regulatory factors Bax, Bcl-xL, or survivin.
|
18160396 |
2008 |
Atrial Premature Complexes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The APC tumor suppressor is well known for its ability to regulate Wnt signaling through mediation of beta-catenin levels in the cell.
|
18474248 |
2008 |