Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
NaHS treatment attenuated bleomycin-induced TGF-β1 production, activation of LRP-6/β-catenin signalling, EMT and lung fibrosis (P < 0.01 except for β-catenin: P < 0.05).
|
30136377 |
2019 |
Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of this study is to explore the target cells of Wnt/β-catenin inhibition in pulmonary fibrosis and to examine the antifibrotic effect of the novel inhibitor PRI-724 specifically disrupting the interaction of β-catenin and CBP.
|
31298961 |
2019 |
Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
It's well-known that Wnt/β-catenin signaling pathway plays an important role in the pathogenesis of pulmonary fibrosis, in which the accumulation of β-catenin in the cytoplasm is an important signal of the activation of Wnt/β-catenin signaling pathway.
|
31550972 |
2019 |
Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tetraspanin 1 as a mediator of fibrosis inhibits EMT process and Smad2/3 and beta-catenin pathway in human pulmonary fibrosis.
|
30869194 |
2019 |
Pulmonary Fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, changes of promoter hypermethylation might downregulate SFRP1 and SFRP4 at different stages of pulmonary fibrosis, and the finding supports the usefulness of DNMT inhibitors, which might effectively reverse activation of β-catenin and reduce pulmonary fibrosis in mice.
|
30586565 |
2019 |
Pulmonary Fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we demonstrated that suppression of the NF-κB signaling could attenuate myofibroblast differentiation of LR-MSCs and bleomycin-induced pulmonary fibrosis which were accompanied with decreased expression of β-catenin.
|
28731277 |
2018 |
Pulmonary Fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In vivo, intratracheal treatment with Lv-miR-29c significantly increased expression of miR-29c, and reduced expression of β-catenin, matrix metalloproteinase (MMP)-2, and MMP-9 in the lung and levels of transforming growth factor-beta 1 (TGF-β1) and interleukin-6 (IL-6) in bronchoalveolar lavage fluid, and notably attenuated pulmonary fibrosis as evidenced by hydroxyproline content in silica-administered mice.
|
29216763 |
2018 |
Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Beta-tubulin-III (Tubβ3), ZEB1, and β-catenin are partially under the negative control of miR-200, a family of micro-RNAs playing a major role in epithelial to mesenchymal transition, that are reduced in experimental lung fibrosis and idiopathic pulmonary fibrosis.
|
27586205 |
2017 |
Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
XIST/miR-139 axis regulates bleomycin (BLM)-induced extracellular matrix (ECM) and pulmonary fibrosis through β-catenin.
|
29029436 |
2017 |
Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A major outcome of this study is improved insight into the mechanisms by which epithelial and mesenchymal cells activated by TGFβ1-smad2/3 signalling through Wnt/β-catenin contribute to lung fibrosis.
|
28244647 |
2017 |
Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our research aimed to determine whether the regulation of HIF-1α in EMT occurs via the Snail and β-catenin pathways in PQ poisoning-induced pulmonary fibrosis.
|
26781174 |
2016 |
Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
β-catenin contributes to the pathogenesis of lung fibrosis.
|
25175023 |
2014 |
Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings reveal that the alveolar epithelium is a relevant source of proinflammatory cytokines induced by active WNT/β-catenin in pulmonary fibrosis.
|
23526221 |
2013 |
Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated β-catenin-dependent and transforming growth factor-β1 (TGF-β1) interactions in pulmonary alveolar epithelial cells (AEC) in the context of EMT and pulmonary fibrosis.
|
22241478 |
2012 |
Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we focus on Wnt/beta-catenin-related pathogenic effects in different organs, such as lung fibrosis, liver fibrosis, skin fibrosis and renal fibrosis.
|
22670697 |
2012 |
Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis.
|
19104148 |
2009 |