CTNNB1, catenin beta 1, 1499

N. diseases: 1368; N. variants: 68
Disease: Vascular calcification ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.340 AlteredExpression phenotype BEFREE Si-WNT8b reduced the levels of WNT8b, frizzled-4, β-catenin, phospho-GSK-3β (p-GSK-3β), and cyclin-D, whereas it increased the levels of p-β-catenin and GSK-3β, indicating that si-WNT8b could alter the Wnt-β-catenin signaling pathway and thus hamper the VC in T/G HA-VSMC, which was further demonstrated by the TOP/FOP-Flash assay and detection of the β-catenin expression level in the nucleus. 30461014 2019
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.340 Biomarker phenotype BEFREE Taken together, our results suggest that HMGB1 is involved in VC associated with CKD via a mechanism involving the β-catenin. 29922171 2018
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.340 AlteredExpression phenotype BEFREE Immunohistochemical stainings demonstrated that increased expressions of β-catenin, GSK-3beta and Wnt-5a were mostly observed in the subjects with vascular calcification. 27156072 2016
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.340 Biomarker phenotype BEFREE BMP-2 plays a crucial role in calcium deposition in VSMCs and VC in CKD patients via a mechanism involving the Wnt/β-catenin pathway. 25562153 2014
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.340 Therapeutic phenotype CTD_human Quercetin attenuates warfarin-induced vascular calcification in vitro independently from matrix Gla protein. 23223575 2013