TTL, tubulin tyrosine ligase, 150465

N. diseases: 13; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 GeneticVariation group BEFREE A prediction algorithm (SUMSCAN) based on the presence of specific gene gains (Tumor Target Charge, TTC) and losses (Tumor Target Losses, TTL) was conceived and validated in 2 independent validation cohorts. 26317543 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 AlteredExpression group BEFREE To understand the molecular and genetic bases of neuroblastoma, we have generated its cDNA libraries and identified a human ortholog of tubulin tyrosine ligase gene (hTTL/Nbla0660) as a differentially expressed gene at high levels in a favorable subset of the tumor. 15382060 2004
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 AlteredExpression group BEFREE We conclude there is a widespread loss of TTL activity during tumor growth in situ, suggesting that TTL activity may play a role in tumor cell regulation. 9405300 1998
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.010 Biomarker disease BEFREE Importantly, catechol-O-methyltransferase, iodotyrosine deiodinase, and tubulin tyrosine ligase showed a significant association with patient survival in publicly available bladder cancer smoker datasets and did not have any clinical association in never smokers. 30642841 2019
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.010 Biomarker disease BEFREE Importantly, catechol-O-methyltransferase, iodotyrosine deiodinase, and tubulin tyrosine ligase showed a significant association with patient survival in publicly available bladder cancer smoker datasets and did not have any clinical association in never smokers. 30642841 2019
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.010 Biomarker disease BEFREE Importantly, catechol-O-methyltransferase, iodotyrosine deiodinase, and tubulin tyrosine ligase showed a significant association with patient survival in publicly available bladder cancer smoker datasets and did not have any clinical association in never smokers. 30642841 2019
CUI: C0016057
Disease: Fibrosarcoma
Fibrosarcoma 		0.010 Biomarker disease BEFREE To validate our finding, the function of one of the candidate genes, tubulin tyrosine ligase (<i>Ttl</i>), was further studied in TAFs from fibrosarcoma, colon, breast and hepatocarcinoma. 29228606 2017
CUI: C0278595
Disease: Adult Fibrosarcoma
Adult Fibrosarcoma 		0.010 Biomarker disease BEFREE To validate our finding, the function of one of the candidate genes, tubulin tyrosine ligase (<i>Ttl</i>), was further studied in TAFs from fibrosarcoma, colon, breast and hepatocarcinoma. 29228606 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.010 Biomarker disease BEFREE To validate our finding, the function of one of the candidate genes, tubulin tyrosine ligase (<i>Ttl</i>), was further studied in TAFs from fibrosarcoma, colon, breast and hepatocarcinoma. 29228606 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 Biomarker group BEFREE Potential role of tubulin tyrosine ligase-like enzymes in tumorigenesis and cancer cell resistance. 24814394 2014
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 Biomarker phenotype BEFREE Potential role of tubulin tyrosine ligase-like enzymes in tumorigenesis and cancer cell resistance. 24814394 2014
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.010 Biomarker group BEFREE Potential role of tubulin tyrosine ligase-like enzymes in tumorigenesis and cancer cell resistance. 24814394 2014
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.010 AlteredExpression disease BEFREE Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis. 15382060 2004
CUI: C1261473
Disease: Sarcoma
Sarcoma 		0.010 Biomarker group BEFREE When injected into nude mice, both TTL- cells and TTL- cells stably transfected with TTL cDNA form sarcomas. 9405300 1998
CUI: C4551686
Disease: Malignant neoplasm of soft tissue
Malignant neoplasm of soft tissue 		0.010 Biomarker group BEFREE When injected into nude mice, both TTL- cells and TTL- cells stably transfected with TTL cDNA form sarcomas. 9405300 1998