CTSB, cathepsin B, 1508

N. diseases: 304; N. variants: 17
Disease: Memory impairment ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.060 Biomarker phenotype BEFREE These results suggest that the increase and leakage of CatB in microglia during aging are responsible for the increased generation of mitochondria-derived ROS and proinflammatory mediators, culminating in memory impairment. 30575263 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.060 AlteredExpression phenotype BEFREE In this study, we investigated the effect of GM6 in a mouse model of AD before the development of amyloid plaques and determined how this treatment affected the accumulation of Aβ peptide and related pathologic changes (e.g., inflammation, nerve growth factor (NGF) expression, cathepsin B, and memory impairment). 30798443 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.060 Biomarker phenotype BEFREE The results support the idea that CatB can speed Aß metabolism through lysosomal pathways and as such reduce AD-associated memory deficits. 27966067 2017
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.060 Biomarker phenotype BEFREE Moreover, CatB knockout and E64d treatment has been previously shown to improve memory deficits in the AβPPLon mice. 24595198 2014
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.060 Biomarker phenotype BEFREE Knockout of the CatB gene in the AβPPWT/Lon mice improved memory deficits and altered the pattern of Aβ-related biomarkers in a manner consistent with CatB having WT β-secretase activity. 22337825 2012
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.060 Biomarker phenotype BEFREE Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease. 20536395 2010