CTSD, cathepsin D, 1509

N. diseases: 242; N. variants: 13
Disease: Retinal toxicity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0877104
Disease: Retinal toxicity
Retinal toxicity 		0.010 Biomarker disease BEFREE Surprisingly, in the enzyme active pH range, LY2811376 forms a stronger salt bridge with the catalytic dyad in CatD than in BACE1, which might explain the retinal toxicity of the inhibitor related to off-target inhibition of CatD. 28370344 2017