|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
We assess the contribution of α2B-adrenergic receptor (Adra2b) in air pollution-associated hypertension and behavioral changes in this study.
|
30812033 |
2019 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
G<sub>s</sub>-coupled GPCR signalling is regulated by G protein-coupled receptor kinases (GRK) and arrestin proteins, and dysregulation of Gs/GPCR signalling is thought play a role in the development of hypertension, which may be a consequence of enhanced GRK2 and/or arrestin expression.
|
30075183 |
2018 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
I/D ACE and ADRA2B polymorphisms were associated with AH.
|
29027816 |
2018 |
|
Hypertensive disease
|
0.300 |
AlteredExpression
|
group |
BEFREE |
G-protein coupled receptor (GPCR) mediated activation of the MAPK signalling cascade is a key pathway in the induction of hypertrophic remodelling of the heart - a response to pathological cues including hypertension and myocardial infarction.
|
28412414 |
2017 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The Del301-303 α2BAR, a human variation that shows impaired phosphorylation and desensitization and is linked to hypertension in certain populations, exhibits preferential interaction with spinophilin over arrestin.
|
26244553 |
2015 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
These include the contribution of variants of the regulator of G protein signaling (RGS) protein to hypertension; the role variants of the activator of G protein signaling (AGS) proteins to phenotypes (such as the type III AGS8 variant to hypoxia); the contribution of G protein-coupled receptor kinase (GRK) proteins, such as GRK4, in disorders such as hypertension.
|
25150869 |
2014 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
To test whether a previously hypertension-linked 23 cM region on chromosome 2 is linked to the metabolic syndrome (MetS) or its individual components, and whether a common I/D polymorphism of the adrenergic receptor 2b (ADRA2B) gene, mapping in that region, is associated with the same traits.
|
19593211 |
2009 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
In the case of the G protein-coupled receptor kinases (GRKs), identified originally in the retinal tissues that converge on rhodopsin, proteins such as GRK4 have been identified that have been subsequently associated with hypertension.
|
18370232 |
2008 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
LHGDN |
Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects.
|
18953403 |
2008 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
In Japanese patients with newly diagnosed, untreated hypertension (n = 184), we studied polymorphisms in 10 genes, including G protein-coupled receptor kinase type 4 (GRK4), some variations of which are associated with hypertension and impair D1 receptor (D1R)-inhibited renal sodium transport.
|
16439609 |
2006 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
In addition, an 'uncoupling' of the G-protein-coupled receptor/G-protein complex is the principal mechanism underlying impaired G-protein-coupled-receptor-mediated vasodilatation in hypertension.
|
16481879 |
2006 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
RGD |
The present experiments were designed to explore the possibility of gene transfection in the brain by intracerebroventricular (ICV) delivery of AS-DNA via adeno-associated virus (AAV) to prolong alpha(2B)-AR inhibition and hence reversal of salt-dependent hypertension.
|
17070424 |
2006 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
We performed an association study between the I/D polymorphism of the alpha(2B)-adrenoceptor and hypertension in the Skaraborg population.
|
14744925 |
2004 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
G-protein-coupled receptor kinases (GRKs) are implicated in the pathophysiology of human diseases such as arterial hypertension, heart failure and rheumatoid arthritis.
|
15225142 |
2004 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
LHGDN |
We performed an association study between the I/D polymorphism of the alpha(2B)-adrenoceptor and hypertension in the Skaraborg population.
|
14744925 |
2004 |