ADRA2B, adrenoceptor alpha 2B, 151

N. diseases: 296; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability 		0.400 Biomarker group CTD_human Deep sequencing reveals 50 novel genes for recessive cognitive disorders. 21937992 2011
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability 		0.400 Biomarker group HPO
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.330 Biomarker disease BEFREE CD97 Promotes Tumor Aggressiveness Through the Traditional G Protein-Coupled Receptor-Mediated Signaling in Hepatocellular Carcinoma. 29704239 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.330 AlteredExpression disease BEFREE Withal, liver clear cell foci of cellular alteration were genuinely associated with HCC and appended to some changes in immune and G protein-coupled receptor gene expression ontologies. 30061721 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.330 Biomarker disease CTD_human Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling. 28284560 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.330 AlteredExpression disease BEFREE We show that SDF-1 G protein-coupled receptor, chemokine (C-X-C motif) receptor 4 (CXCR4), and SDF-1 mRNA are expressed in human hepatoma Huh7 cells, which secrete and bind SDF-1. 17259344 2007
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.320 Biomarker group BEFREE Dominant pathways associated with these epigenetic changes include those linked to G-protein coupled receptor signaling, aryl hydrocarbon receptor signaling and xenobiotic metabolism signaling, all of which have been associated with cigarette smoking and lung disease. 28273093 2017
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.320 Biomarker group BEFREE LPAR6, a G protein coupled receptor, associated with lung disease severity (false discovery rate q value = 0.0006). 25640674 2015
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.320 Biomarker group CTD_human {Alpha}2B-adrenoceptor deficiency leads to postnatal respiratory failure in mice. 20729197 2010
CUI: C1842852
Disease: EPILEPSY, MYOCLONIC, BENIGN ADULT FAMILIAL, TYPE 2
EPILEPSY, MYOCLONIC, BENIGN ADULT FAMILIAL, TYPE 2 		0.310 Biomarker disease BEFREE We performed a systematic review and meta-analysis of individual patient data (IPD) of the three available randomized trials of contemporary FFR-guided PCI vs. medical therapy for patients with stable coronary lesions: FAME 2 (NCT01132495), DANAMI-3-PRIMULTI (NCT01960933), and Compare-Acute (NCT01399736). 30596995 2019
CUI: C1842852
Disease: EPILEPSY, MYOCLONIC, BENIGN ADULT FAMILIAL, TYPE 2
EPILEPSY, MYOCLONIC, BENIGN ADULT FAMILIAL, TYPE 2 		0.310 Biomarker disease GENOMICS_ENGLAND Autosomal dominant cortical myoclonus and epilepsy (ADCME) with complex partial and generalized seizures: A newly recognized epilepsy syndrome with linkage to chromosome 2p11.1-q12.2. 11701600 2001
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 Biomarker group BEFREE We assess the contribution of α2B-adrenergic receptor (Adra2b) in air pollution-associated hypertension and behavioral changes in this study. 30812033 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 Biomarker group BEFREE G<sub>s</sub>-coupled GPCR signalling is regulated by G protein-coupled receptor kinases (GRK) and arrestin proteins, and dysregulation of Gs/GPCR signalling is thought play a role in the development of hypertension, which may be a consequence of enhanced GRK2 and/or arrestin expression. 30075183 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 GeneticVariation group BEFREE I/D ACE and ADRA2B polymorphisms were associated with AH. 29027816 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 AlteredExpression group BEFREE G-protein coupled receptor (GPCR) mediated activation of the MAPK signalling cascade is a key pathway in the induction of hypertrophic remodelling of the heart - a response to pathological cues including hypertension and myocardial infarction. 28412414 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 GeneticVariation group BEFREE The Del301-303 α2BAR, a human variation that shows impaired phosphorylation and desensitization and is linked to hypertension in certain populations, exhibits preferential interaction with spinophilin over arrestin. 26244553 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 Biomarker group BEFREE These include the contribution of variants of the regulator of G protein signaling (RGS) protein to hypertension; the role variants of the activator of G protein signaling (AGS) proteins to phenotypes (such as the type III AGS8 variant to hypoxia); the contribution of G protein-coupled receptor kinase (GRK) proteins, such as GRK4, in disorders such as hypertension. 25150869 2014
CUI: C1832841
Disease: EPILEPSY, FAMILIAL ADULT MYOCLONIC, 1
EPILEPSY, FAMILIAL ADULT MYOCLONIC, 1 		0.300 GermlineCausalMutation disease ORPHANET The α2B-adrenergic receptor is mutant in cortical myoclonus and epilepsy. 24114805 2014
CUI: C0020796
Disease: Profound Mental Retardation
Profound Mental Retardation 		0.300 Biomarker disease CTD_human Deep sequencing reveals 50 novel genes for recessive cognitive disorders. 21937992 2011
CUI: C0025363
Disease: Mental Retardation, Psychosocial
Mental Retardation, Psychosocial 		0.300 Biomarker phenotype CTD_human Deep sequencing reveals 50 novel genes for recessive cognitive disorders. 21937992 2011
CUI: C0917816
Disease: Mental deficiency
Mental deficiency 		0.300 Biomarker disease CTD_human Deep sequencing reveals 50 novel genes for recessive cognitive disorders. 21937992 2011
CUI: C0010520
Disease: Cyanosis
Cyanosis 		0.300 Biomarker phenotype CTD_human {Alpha}2B-adrenoceptor deficiency leads to postnatal respiratory failure in mice. 20729197 2010
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 GeneticVariation group BEFREE To test whether a previously hypertension-linked 23 cM region on chromosome 2 is linked to the metabolic syndrome (MetS) or its individual components, and whether a common I/D polymorphism of the adrenergic receptor 2b (ADRA2B) gene, mapping in that region, is associated with the same traits. 19593211 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 GeneticVariation group BEFREE In the case of the G protein-coupled receptor kinases (GRKs), identified originally in the retinal tissues that converge on rhodopsin, proteins such as GRK4 have been identified that have been subsequently associated with hypertension. 18370232 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 GeneticVariation group LHGDN Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects. 18953403 2008