|
Liver carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
CD97 Promotes Tumor Aggressiveness Through the Traditional G Protein-Coupled Receptor-Mediated Signaling in Hepatocellular Carcinoma.
|
29704239 |
2018 |
|
Liver carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Withal, liver clear cell foci of cellular alteration were genuinely associated with HCC and appended to some changes in immune and G protein-coupled receptor gene expression ontologies.
|
30061721 |
2018 |
|
Liver carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
We show that SDF-1 G protein-coupled receptor, chemokine (C-X-C motif) receptor 4 (CXCR4), and SDF-1 mRNA are expressed in human hepatoma Huh7 cells, which secrete and bind SDF-1.
|
17259344 |
2007 |
|
Lung diseases
|
0.320 |
Biomarker
|
group |
BEFREE |
Dominant pathways associated with these epigenetic changes include those linked to G-protein coupled receptor signaling, aryl hydrocarbon receptor signaling and xenobiotic metabolism signaling, all of which have been associated with cigarette smoking and lung disease.
|
28273093 |
2017 |
|
Lung diseases
|
0.320 |
Biomarker
|
group |
BEFREE |
LPAR6, a G protein coupled receptor, associated with lung disease severity (false discovery rate q value = 0.0006).
|
25640674 |
2015 |
|
EPILEPSY, MYOCLONIC, BENIGN ADULT FAMILIAL, TYPE 2
|
0.310 |
Biomarker
|
disease |
BEFREE |
We performed a systematic review and meta-analysis of individual patient data (IPD) of the three available randomized trials of contemporary FFR-guided PCI vs. medical therapy for patients with stable coronary lesions: FAME 2 (NCT01132495), DANAMI-3-PRIMULTI (NCT01960933), and Compare-Acute (NCT01399736).
|
30596995 |
2019 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
We assess the contribution of α2B-adrenergic receptor (Adra2b) in air pollution-associated hypertension and behavioral changes in this study.
|
30812033 |
2019 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
G<sub>s</sub>-coupled GPCR signalling is regulated by G protein-coupled receptor kinases (GRK) and arrestin proteins, and dysregulation of Gs/GPCR signalling is thought play a role in the development of hypertension, which may be a consequence of enhanced GRK2 and/or arrestin expression.
|
30075183 |
2018 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
I/D ACE and ADRA2B polymorphisms were associated with AH.
|
29027816 |
2018 |
|
Hypertensive disease
|
0.300 |
AlteredExpression
|
group |
BEFREE |
G-protein coupled receptor (GPCR) mediated activation of the MAPK signalling cascade is a key pathway in the induction of hypertrophic remodelling of the heart - a response to pathological cues including hypertension and myocardial infarction.
|
28412414 |
2017 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The Del301-303 α2BAR, a human variation that shows impaired phosphorylation and desensitization and is linked to hypertension in certain populations, exhibits preferential interaction with spinophilin over arrestin.
|
26244553 |
2015 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
These include the contribution of variants of the regulator of G protein signaling (RGS) protein to hypertension; the role variants of the activator of G protein signaling (AGS) proteins to phenotypes (such as the type III AGS8 variant to hypoxia); the contribution of G protein-coupled receptor kinase (GRK) proteins, such as GRK4, in disorders such as hypertension.
|
25150869 |
2014 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
To test whether a previously hypertension-linked 23 cM region on chromosome 2 is linked to the metabolic syndrome (MetS) or its individual components, and whether a common I/D polymorphism of the adrenergic receptor 2b (ADRA2B) gene, mapping in that region, is associated with the same traits.
|
19593211 |
2009 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
In the case of the G protein-coupled receptor kinases (GRKs), identified originally in the retinal tissues that converge on rhodopsin, proteins such as GRK4 have been identified that have been subsequently associated with hypertension.
|
18370232 |
2008 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
In Japanese patients with newly diagnosed, untreated hypertension (n = 184), we studied polymorphisms in 10 genes, including G protein-coupled receptor kinase type 4 (GRK4), some variations of which are associated with hypertension and impair D1 receptor (D1R)-inhibited renal sodium transport.
|
16439609 |
2006 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
In addition, an 'uncoupling' of the G-protein-coupled receptor/G-protein complex is the principal mechanism underlying impaired G-protein-coupled-receptor-mediated vasodilatation in hypertension.
|
16481879 |
2006 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
We performed an association study between the I/D polymorphism of the alpha(2B)-adrenoceptor and hypertension in the Skaraborg population.
|
14744925 |
2004 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
G-protein-coupled receptor kinases (GRKs) are implicated in the pathophysiology of human diseases such as arterial hypertension, heart failure and rheumatoid arthritis.
|
15225142 |
2004 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The human A<sub>3</sub> adenosine receptor is a G protein-coupled receptor involved in many physio-pathological conditions, e.g. cancer and inflammation, thus representing a promising research target.
|
31787357 |
2020 |
|
Congestive heart failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Molecular signaling of G-protein-coupled receptor in chronic heart failure and associated complications.
|
31785110 |
2020 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Kaposi's sarcoma-associated herpesvirus G-protein-coupled receptor (vGPCR) is a key molecule in the pathogenesis of Kaposi's sarcoma.
|
31838186 |
2020 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The human A<sub>3</sub> adenosine receptor is a G protein-coupled receptor involved in many physio-pathological conditions, e.g. cancer and inflammation, thus representing a promising research target.
|
31787357 |
2020 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we overview the recent advances provided by the information theory, focusing on the nuclear factor (NF)-κB, extracellular signal-regulated kinase (ERK), and G-protein-coupled receptor (GPCR) pathways, which are frequently hijacked in cancer.
|
31630880 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, we recognize the importance of several kinase inhibitors to the current landscape of drug development for cancer therapy and the use of G-protein Coupled Receptor (GPCR) modulators.
|
31659944 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Accordingly, multiple studies using animal models have demonstrated that UT antagonists may have utility as potential therapeutic agents for treating atherosclerosis, pulmonary arterial hypertension, heart failure, and cancer.
|
31500846 |
2019 |