CTSL, cathepsin L, 1514

N. diseases: 225; N. variants: 0
Disease: Hyperthyroidism ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism 		0.200 Biomarker disease RGD We tested the hypotheses that experimental hyperthyroidism in rats, induced by daily intraperitoneal injections of 100 microg/100 g body weight of triiodothyronine (T3), upregulates the expression of atrogin-1 and MuRF1 in skeletal muscle and stimulates lysosomal, including cathepsin L, calpain-, and caspase-3-dependent protein breakdown in addition to proteasome-dependent protein breakdown. 19777444 2009