ADRA2C, adrenoceptor alpha 2C, 152

N. diseases: 40; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.380 GeneticVariation disease BEFREE The mortality rate of chronic systolic HF patients carrying no α(2c)-adrenoceptor Del322-325 alleles was significantly higher (almost 2.5-fold) than that of HF patients carrying ≥1 allele. 23207081 2012
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.380 GeneticVariation disease BEFREE A four-amino acid deletion was identified within the alpha 2C-adrenergic receptor (alpha 2C Del322-325) that, when homozygous, increases the risk of heart failure in African-Americans nearly six-fold. 18320080 2009
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.380 GeneticVariation disease BEFREE The alpha(2C) Del322-325 polymorphism exclusively or in combination with the beta(1)Arg389 allele is not associated with an increased risk of adverse events in HF. 19477404 2009
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.380 Biomarker disease BEFREE Genotypes and haplotypes of ADRB1, ADRB2, and ADRA2C did not significantly affect survival in metoprolol-treated or carvedilol-treated HF patients in this study. 18702968 2008
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.380 Biomarker disease BEFREE The purpose of this study was to investigate possible synergistic effects of polymorphisms of these two intronless genes (ADRB1 and ADRA2C, respectively) on the risk of death/transplant in heart failure patients. 18947427 2008
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.380 GeneticVariation disease BEFREE We tested whether the ADRA2C insertion/deletion polymorphism was associated with beta-blocker response in heart failure, either alone or in combination with the ADRB1Arg389Gly polymorphism. 17496726 2007
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.380 GeneticVariation disease BEFREE We determined the beta(1)-, beta(2)-, and alpha(2C)-adrenoceptor genotype in 60 patients with severe CHF in conjunction with measurement of cardiac and systemic sympathetic activity using the radiotracer norepinephrine spillover method. 15542284 2004
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.380 Biomarker disease BEFREE Patients with a deletion of 4 consecutive amino acids in the gene encoding for the alpha(2C)-adrenergic receptor (alpha(2C)Del322-325) have an increased prevalence of clinical heart failure, worse clinical status, and a lower left ventricular ejection fraction compared with patients without this deletion. 14668769 2004
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.380 Biomarker disease CTD_human Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. 12374873 2002
CUI: C0018801
Disease: Heart failure
Heart failure 		0.370 GeneticVariation disease BEFREE The mortality rate of chronic systolic HF patients carrying no α(2c)-adrenoceptor Del322-325 alleles was significantly higher (almost 2.5-fold) than that of HF patients carrying ≥1 allele. 23207081 2012
CUI: C0018801
Disease: Heart failure
Heart failure 		0.370 GeneticVariation disease BEFREE The alpha(2C) Del322-325 polymorphism exclusively or in combination with the beta(1)Arg389 allele is not associated with an increased risk of adverse events in HF. 19477404 2009
CUI: C0018801
Disease: Heart failure
Heart failure 		0.370 GeneticVariation disease BEFREE A four-amino acid deletion was identified within the alpha 2C-adrenergic receptor (alpha 2C Del322-325) that, when homozygous, increases the risk of heart failure in African-Americans nearly six-fold. 18320080 2009
CUI: C0018801
Disease: Heart failure
Heart failure 		0.370 Biomarker disease BEFREE Genotypes and haplotypes of ADRB1, ADRB2, and ADRA2C did not significantly affect survival in metoprolol-treated or carvedilol-treated HF patients in this study. 18702968 2008
CUI: C0018801
Disease: Heart failure
Heart failure 		0.370 Biomarker disease BEFREE The purpose of this study was to investigate possible synergistic effects of polymorphisms of these two intronless genes (ADRB1 and ADRA2C, respectively) on the risk of death/transplant in heart failure patients. 18947427 2008
CUI: C0018801
Disease: Heart failure
Heart failure 		0.370 GeneticVariation disease BEFREE We tested whether the ADRA2C insertion/deletion polymorphism was associated with beta-blocker response in heart failure, either alone or in combination with the ADRB1Arg389Gly polymorphism. 17496726 2007
CUI: C0018801
Disease: Heart failure
Heart failure 		0.370 Biomarker disease BEFREE Patients with a deletion of 4 consecutive amino acids in the gene encoding for the alpha(2C)-adrenergic receptor (alpha(2C)Del322-325) have an increased prevalence of clinical heart failure, worse clinical status, and a lower left ventricular ejection fraction compared with patients without this deletion. 14668769 2004
CUI: C0018801
Disease: Heart failure
Heart failure 		0.370 Biomarker disease CTD_human Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. 12374873 2002
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 Biomarker disease PSYGENET Six kindreds containing multiple cases of manic-depressive illness were genotyped with highly polymorphic microsatellite polymorphisms for the D5 dopamine and alpha 2C-adrenergic receptor genes. 7719697 1994
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 GeneticVariation disease BEFREE Six kindreds containing multiple cases of manic-depressive illness were genotyped with highly polymorphic microsatellite polymorphisms for the D5 dopamine and alpha 2C-adrenergic receptor genes. 7719697 1994
CUI: C0016059
Disease: Fibrosis
Fibrosis 		0.300 Biomarker phenotype CTD_human Transgenic mice expressing alpha(2A)-adrenoceptors under control of the dopamine beta-hydroxylase (Dbh) promoter were generated and crossed with mice carrying a constitutive deletion in the alpha(2A)- and alpha(2C)-adrenoceptor genes. alpha(2AC)-deficient mice showed increased norepinephrine plasma levels, cardiac hypertrophy, and fibrosis at baseline. 20083574 2010
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.300 Biomarker phenotype CTD_human Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload. 20083574 2010
CUI: C1383860
Disease: Cardiac Hypertrophy
Cardiac Hypertrophy 		0.300 Biomarker phenotype CTD_human Transgenic mice expressing alpha(2A)-adrenoceptors under control of the dopamine beta-hydroxylase (Dbh) promoter were generated and crossed with mice carrying a constitutive deletion in the alpha(2A)- and alpha(2C)-adrenoceptor genes. alpha(2AC)-deficient mice showed increased norepinephrine plasma levels, cardiac hypertrophy, and fibrosis at baseline. 20083574 2010
CUI: C1623038
Disease: Cirrhosis
Cirrhosis 		0.300 Biomarker disease CTD_human Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload. 20083574 2010
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.300 Biomarker group PSYGENET Further, several genome scans for mood disorders, both unipolar and bipolar, have indicated linkage to the chromosomal regions of 5q23-q33.3, 8p12-p11.2, 4p16, and 10q24-q26, the location of the adrenergic receptors alpha1B (ADRA1B), beta3 (ADRB3), alpha2C (ADRA2C), alpha2A (ADRA2A), and beta1 (ADRB1). 16526032 2006
CUI: C0023212
Disease: Left-Sided Heart Failure
Left-Sided Heart Failure 		0.300 Biomarker disease CTD_human Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. 12374873 2002