|
Obesity
|
0.350 |
Biomarker
|
disease |
BEFREE |
Cathepsin S correlates with central obesity and contributes to the formation and progression of atherosclerosis.
|
30549421 |
2019 |
|
Obesity
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
CTSS variants seem to be nominally associated to obesity related traits and this association may be modified by dietary protein intake.
|
22844403 |
2012 |
|
Obesity
|
0.350 |
Biomarker
|
disease |
CTD_human |
Fate and complex pathogenic effects of dioxins and polychlorinated biphenyls in obese subjects before and after drastic weight loss.
|
21156398 |
2011 |
|
Obesity
|
0.350 |
Biomarker
|
disease |
BEFREE |
Cathepsin S circulating concentrations were increased with obesity (+30%) and reduced after weight reduction (P < 0.05 for both).
|
20164293 |
2010 |
|
Obesity
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
This study used five tag single nucleotide polymorphisms (tSNPs) to screen the CTSS gene in healthy lean (n = 1891) and obese French populations (n = 477) for their association with various phenotypes: body mass index, waist-to-hip ratio, glycemia, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (Apo-A1) and apolipoprotein B.
|
18565099 |
2008 |
|
Obesity
|
0.350 |
Biomarker
|
disease |
BEFREE |
Since this enzyme has been implicated in the development of atherosclerotic lesions, we propose that cathepsin S represents a molecular link between obesity and atherosclerosis.
|
15985526 |
2005 |
|
Contact Dermatitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay.
|
25724174 |
2015 |
|
Contact hypersensitivity
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay.
|
25724174 |
2015 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Neoplasm Invasiveness
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9.
|
19700239 |
2010 |
|
Hyperalgesia
|
0.220 |
AlteredExpression
|
phenotype |
BEFREE |
Spinal delivery of irreversible CatS inhibitor LHVS reduced hyperalgesia, attenuated activation of spinal microglia and blocked phosphorylation of NMDA receptor NR1 subunit induced by remifentanil.
|
28039043 |
2017 |
|
Hyperalgesia
|
0.220 |
Biomarker
|
phenotype |
BEFREE |
Intraplantar injection of Cat-S caused inflammation and hyperalgesia in mice that was attenuated by PAR2 or TRPV4 deletion and adenylyl cyclase inhibition.
|
25118282 |
2014 |
|
Hyperalgesia
|
0.220 |
Biomarker
|
phenotype |
RGD |
Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model.
|
22213084 |
2012 |
|
Intracranial Aneurysm
|
0.200 |
Biomarker
|
disease |
RGD |
Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms.
|
18635848 |
2008 |
|
Neuralgia
|
0.200 |
Biomarker
|
phenotype |
RGD |
Differential expression of Cathepsin S and X in the spinal cord of a rat neuropathic pain model.
|
18700000 |
2008 |
|
Neuralgia
|
0.200 |
Biomarker
|
phenotype |
RGD |
Here, we report that in peripheral nerve-injured rats, the lysosomal cysteine protease cathepsin S (CatS) is critical for the maintenance of neuropathic pain and spinal microglia activation.
|
17551020 |
2007 |
|
Muscular Dystrophy, Duchenne
|
0.200 |
Biomarker
|
disease |
MGD |
|
|
|
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Further <i>in silico</i> gene expression analysis, using both in-house and publicly available datasets, confirmed these observations and suggested high CTSS expression may also be beneficial to outcome in ER-/HER2+ cancer.
|
31346333 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As a member of the cysteine protease family, cathepsin S (CTSS) serves an important role in diseases such as cancer, arthritis and atherosclerosis.
|
31115520 |
2019 |
|
Basal cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Combined analysis of keratinocyte cancers identifies novel genome-wide loci.
|
31174203 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Depletion of CTSS by shRNA delayed tumor growth in a xenograft mouse model, only in the presence of functional BRCA1.
|
30006610 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Finally, analysis of matching IHC analysis reveals an increased M1 (tumour destructive) polarisation in macrophage in patients exhibiting high epithelial CTSS expression.
|
31346333 |
2019 |
|
Basal Cell Neoplasm
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Combined analysis of keratinocyte cancers identifies novel genome-wide loci.
|
31174203 |
2019 |
|
Basal Cell Cancer
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Combined analysis of keratinocyte cancers identifies novel genome-wide loci.
|
31174203 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the role of circulating CS in cancer growth is not clear.
|
29181829 |
2018 |