CTSS, cathepsin S, 1520

N. diseases: 131; N. variants: 10
Disease: Hyperalgesia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.220 AlteredExpression phenotype BEFREE Spinal delivery of irreversible CatS inhibitor LHVS reduced hyperalgesia, attenuated activation of spinal microglia and blocked phosphorylation of NMDA receptor NR1 subunit induced by remifentanil. 28039043 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.220 Biomarker phenotype BEFREE Intraplantar injection of Cat-S caused inflammation and hyperalgesia in mice that was attenuated by PAR2 or TRPV4 deletion and adenylyl cyclase inhibition. 25118282 2014
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.220 Biomarker phenotype RGD Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model. 22213084 2012