CTSS, cathepsin S, 1520

N. diseases: 131; N. variants: 10
Disease: Chronic Obstructive Airway Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.040 AlteredExpression disease BEFREE Despite the presence of an oxidizing environment, CatS expression and activity were significantly higher in current smokers (both non-COPD and COPD) compared with never-smokers, and correlated positively with smoking history. 31553637 2019
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.040 AlteredExpression disease BEFREE <b>Methods:</b> CTSS expression was investigated in animal and human tissue and cell models of COPD. 30641028 2019
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.040 GeneticVariation disease BEFREE A highly significant association between Cathepsin S gene polymorphisms rs12068264 and chronic obstructive pulmonary disease susceptibility in Han Chinese population. 29976774 2018
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.040 GeneticVariation disease BEFREE In this study, functional polymorphisms in the 5'-flanking region of the human cathepsin S gene were identified and their association with COPD phenotypes was investigated. 18410260 2008