GLIPR2, GLI pathogenesis related 2, 152007

N. diseases: 6; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma 		0.020 Biomarker disease BEFREE Glioma pathogenesis related-2 (GLIPR-2) belongs to pathogenesis related-1 (PR-1) family whose function remains unknown. 24204846 2013
CUI: C0017638
Disease: Glioma
Glioma 		0.020 Biomarker disease BEFREE Glioma pathogenesis related-2 (GLIPR-2) has been shown to be up-regulated in proximal tubular cells (PTCs) in the fibrotic kidney. 23516513 2013
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.010 AlteredExpression disease BEFREE In this study, we found that GLIPR-2 expression is elevated in the kidney tissue samples of patients with diabetic nephropathy (DN). 23516513 2013
CUI: C0151650
Disease: Renal fibrosis
Renal fibrosis 		0.010 Biomarker disease BEFREE GLIPR-2 may be responsible for the development of renal fibrosis by increasing the accumulation of interstitial fibroblasts. 23516513 2013
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 Biomarker phenotype BEFREE However, whether GLIPR-2 could induce type 3 EMT in carcinogenesis needs further investigation. 24204846 2013
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.010 Biomarker phenotype BEFREE Taken together, we provide evidence for a hypoxia/GLIPR-2/EMT/migration and invasion axis in HCC cells and it provides novel insights into the mechanism of migration and invasion of hepatocellular carcinoma cells in hypoxia condition. 24204846 2013
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.010 AlteredExpression disease BEFREE In this study, we showed that GLIPR-2 was expressed in hepatocellular carcinoma (HCC) tissues, hypoxia could upregulate the expression of GLIPR-2 in HepG2 and PLC/PRF/5 cells in vitro, overexpression of this protein promoted migration and invasion via EMT, knockdown of GLIPR-2 attenuated migration and invasion of HepG2 and PLC/PRF/5 cells in hypoxia. 24204846 2013