CX3CR1, C-X3-C motif chemokine receptor 1, 1524

N. diseases: 310; N. variants: 10
Disease: Pain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030193
Disease: Pain
Pain 		0.250 Biomarker phenotype BEFREE Chemokine CX3CL1 and its receptor CX3CR1 in the lumbar spinal cord play crucial roles in pain processing. 31564958 2019
CUI: C0030193
Disease: Pain
Pain 		0.250 Biomarker phenotype BEFREE CX3CR1 might be involved in blocking the transition from acute pain to persistent pain in the LPS group. 30852731 2019
CUI: C0030193
Disease: Pain
Pain 		0.250 Biomarker phenotype BEFREE Our work suggests the potential clinical application of NF-κB inhibitors or CX3CR1-neutralizing antibodies in treating pathological pain. 28612319 2018
CUI: C0030193
Disease: Pain
Pain 		0.250 Biomarker phenotype BEFREE Neuron-microglia crosstalk, mediated by the purinergic P2X7 receptor (R)/fractalkine/CX3CR1 cascade in the spinal cord dorsal horn, plays a pivotal role in pain processing. 28028627 2017
CUI: C0030193
Disease: Pain
Pain 		0.250 Biomarker phenotype RGD Our results suggest that intrathecal injection of anti-CX3CR1 neutralizing antibody delayed and attenuated pain facilitation in the rat tibial bone cancer pain model. 20736819 2010
CUI: C0030193
Disease: Pain
Pain 		0.250 Biomarker phenotype BEFREE Neuro-immunoreactivity for fractalkine and CX3CR1 was strongest in patients suffering from severe pain and pancreatic neuritis. 19153557 2009