|
Alcohol consumption
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.
|
28485404 |
2017 |
|
Allergic rhinitis (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The present study was performed to evaluate the potential association between specific single nucleotide polymorphisms (SNPs) in the TNFSF4 and BKL genes with susceptibility to AR in Chinese subjects.
|
28713926 |
2017 |
|
Anaplastic thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to assess FGF19, FGFR4 and βKL concentrations in a group of 36 patients with papillary thyroid cancer (PTC), 11 patients with follicular thyroid cancer (FTC), 9 patients with anaplastic thyroid cancer (ATC) and a group of 19 subjects with multinodular nontoxic goiter (MNG).
|
29438906 |
2018 |
|
Autosomal dominant hypophosphatemic rickets
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mutations in Klotho/beta-Klotho or fgf19, -21, or -23 are associated with a number of human diseases, including autosomal dominant hypophosphatemic rickets, premature aging disorders, and diabetes.
|
21177529 |
2011 |
|
Benign Prostatic Hyperplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We determined that βKlotho expression was significantly decreased in PCa tissues compared with benign prostatic hyperplasia (BPH) tissues, and low βKlotho expression was associated with a high Gleason score of PCa.
|
29749458 |
2018 |
|
Blood urea nitrogen measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
|
31152163 |
2019 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
KLB interacts with FGFR4 to induce apoptosis and inhibit the proliferation of hepatoma cells, and KLA has been demonstrated to be a tumor suppressor in human breast cancer; however, little is known regarding the role of KLB in breast cancer.
|
29344186 |
2017 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Quantitative real-time RT-PCR of ITGA7, SVEP1, TNS1, LPHN3, SEMA3G, KLB and MMP13 mRNA expression in breast cancer.
|
23317273 |
2012 |
|
Caffeine related disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Sub-phenotype analyses targeting the alcohol, caffeine and sweetener components of beverages yielded additional loci: (i) four loci for bitter alcoholic beverages (GCKR, KLB, ADH1B and AGBL2); (ii) five loci for bitter non-alcoholic beverages (ANXA9, AHR, POR, CYP1A1/2 and CSDC2); (iii) 10 loci for coffee; six novel loci (SEC16B, TMEM18, OR8U8, AKAP6, MC4R and SPECC1L-ADORA2A); (iv) FTO for SSBs.
|
31046077 |
2019 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Several studies have investigated the role of βKlotho, an FGF/FGFR signaling co‑receptor in tumorigenesis.
|
29749458 |
2018 |
|
Cartilage-hair hypoplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We thus hypothesized that the metabolic FGF21/KLB/FGFR1 pathway is involved in CHH Genetic screening of 334 CHH patients identified seven heterozygous loss-of-function <i>KLB</i> mutations in 13 patients (4%).
|
28754744 |
2017 |
|
Cholestasis of pregnancy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, our aim was to investigate the circulating FGF-19 and β-klotho levels in intrahepatic cholestasis of pregnancy (ICP) cases.
|
30697260 |
2019 |
|
Congenital hypogonadotropic hypogonadism
|
0.310 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
KLB, encoding β-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism.
|
28754744 |
2017 |
|
Congenital hypogonadotropic hypogonadism
|
0.310 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Congenital hypogonadotropic hypogonadism
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
<i>KLB</i>, encoding β-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism.
|
28754744 |
2017 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mutations in Klotho/beta-Klotho or fgf19, -21, or -23 are associated with a number of human diseases, including autosomal dominant hypophosphatemic rickets, premature aging disorders, and diabetes.
|
21177529 |
2011 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Mutations in Klotho/beta-Klotho or fgf19, -21, or -23 are associated with a number of human diseases, including autosomal dominant hypophosphatemic rickets, premature aging disorders, and diabetes.
|
21177529 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In WAT, overweight/obesity with and without type 2 diabetes led to reduced expression of KLB, but increased FGFR1c expression.
|
28721439 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Our findings indicate that serum Klotho levels were associated with the development of T2DM, and long-term control of blood glucose will be beneficial in ameliorating changes to α-Klotho and β-Klotho levels in patients with T2DM and complications.
|
30042059 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Serum levels of α-Klotho and β-Klotho are down-regulated in patients with T2DM.
|
27916483 |
2017 |
|
Diarrhea
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Variants in KLB and FGFR4 genes (that determine the functional re-uptake of BA in the portal circulation by hepatocytes) are also demonstrated to be associated with (75)SeHCAT retention, confirming a second potential mechanism for the development of BA diarrhea.
|
27018117 |
2016 |
|
Diarrhea
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Thus exome sequencing identified additional variants in KLB and FGFR4 associated with bile acids or colonic transit in IBS-D.
|
24200957 |
2014 |
|
Diarrhoea predominant irritable bowel syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to test the hypothesis that colesevelam's slowing effects on CT in IBS-D patients is influenced by genetic variants in KLB and FGFR4.
|
22271411 |
2012 |
|
Diarrhoea predominant irritable bowel syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Interaction tests of KLB rs17618244 with 3 nonsynonymous SNPs of fibroblast growth factor receptor 4 (FGFR4) revealed that rs1966265 (Val10Ile) and rs351855 (Gly388Arg) modulate rs1768244's association with colonic transit in IBS-D (P=.0025 and P=.0023, respectively).
|
21396369 |
2011 |
|
Follicular thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to assess FGF19, FGFR4 and βKL concentrations in a group of 36 patients with papillary thyroid cancer (PTC), 11 patients with follicular thyroid cancer (FTC), 9 patients with anaplastic thyroid cancer (ATC) and a group of 19 subjects with multinodular nontoxic goiter (MNG).
|
29438906 |
2018 |