ADRB1, adrenoceptor beta 1, 153

N. diseases: 130; N. variants: 3
Disease: Atrial Fibrillation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.060 GeneticVariation disease BEFREE GENETIC-AF is the first randomized trial of pharmacogenetic guided rhythm control, and will test the safety and efficacy of bucindolol compared with metoprolol succinate for the prevention of recurrent symptomatic AF/AFL in patients with HFrEF and an ADRB1 Arg389Arg genotype.(ClinicalTrials.govNCT01970501). 29754666 2018
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.060 GeneticVariation disease BEFREE Genetic variation in the β1-adrenergic receptor is associated with the risk of atrial fibrillation after cardiac surgery. 24332148 2014
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.060 GeneticVariation disease BEFREE Participants were genotyped for common AF susceptibility alleles at chromosomes 4q25 (near PITX2), 16q22 (in ZFHX3), and 1q21 (in KCNN3), and common SNPs in the β1-adrenergic receptor (ARDB1). 24910551 2014
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.060 GeneticVariation disease BEFREE This pharmacogenetic substudy of the prospective, double-blind, randomized CIBIS-ELD trial determined the impact of the β1-adrenoceptor Arg189Gly polymorphism on heart-rate responses to bisoprolol or carvedilol in elderly patients with heart failure (421 with sinus rhythm, 107 with atrial fibrillation). 22617224 2012
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.060 GeneticVariation disease BEFREE We have identified a common β1-AR polymorphism, G389R, that is associated with adequate response to rate-control therapy in AF patients. 22192668 2012
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.060 GeneticVariation disease BEFREE Heterozygous genotype (Ser49Gly) of ADRB1 gene can be considered as one of the genetic predictors for development of primary or secondary AF. 20384459 2010