CYBA, cytochrome b-245 alpha chain, 1535

N. diseases: 177; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1844385
Disease: Absence of bactericidal oxidative respiratory burst in phagocytes
Absence of bactericidal oxidative respiratory burst in phagocytes 		0.100 Biomarker phenotype HPO
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.010 GeneticVariation disease BEFREE A lot of studies have demonstrated that C242T polymorphism in CYBA genes may play an important role in the pathological process of acute coronary syndrome (ACS). 25990054 2015
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.010 GeneticVariation disease BEFREE Meta-analysis of C242T polymorphism in CYBA genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians. 25990054 2015
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.010 GeneticVariation disease BEFREE C242T polymorphism of p22phox gene of NADPH oxidase is a novel genetic marker associated with reduced susceptibility to AMI. 24415302 2014
CUI: C0001342
Disease: Acute periodontitis
Acute periodontitis 		0.010 GeneticVariation disease BEFREE C242T p22phox NADPH oxidase and FcgammaR polymorphisms may predispose to AgP through a modulation of neutrophil superoxide production. 16899095 2006
CUI: C0206667
Disease: Adrenal Cortical Adenoma
Adrenal Cortical Adenoma 		0.010 AlteredExpression disease BEFREE p22phox gene and protein expression were higher (31% and 53%, respectively) in the adrenal adenoma. 19625761 2010
CUI: C0220605
Disease: Adult Non-Hodgkin Lymphoma
Adult Non-Hodgkin Lymphoma 		0.010 GeneticVariation disease BEFREE Of clinical importance, the outcome of patients suffering from non-Hodgkin lymphoma and treated with CHO(E)P regimen was dependent on the CYBA 640A>G polymorphism. 20215507 2010
CUI: C0031106
Disease: Aggressive Periodontitis
Aggressive Periodontitis 		0.010 GeneticVariation disease BEFREE C242T p22phox NADPH oxidase and FcgammaR polymorphisms may predispose to AgP through a modulation of neutrophil superoxide production. 16899095 2006
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.010 Biomarker disease BEFREE We sought to characterize the involvement of NADPH oxidase in allergic asthma by studying the role of CYBA (p22phox) in human asthma and murine house dust mite (HDM)-induced allergic airway inflammation. 28510479 2017
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker disease CTD_human Vascular NADH oxidase is involved in impaired endothelium-dependent vasodilation in OLETF rats, a model of type 2 diabetes. 11812764 2002
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker disease CTD_human Relationship between peroxisome proliferator-activated receptors (PPAR alpha and PPAR gamma) and endothelium-dependent relaxation in streptozotocin-induced diabetic rats. 12967931 2003
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.010 GeneticVariation disease BEFREE Association of the p22phox polymorphism C242T with the risk of late-onset Alzheimer's disease in a northern Han Chinese population. 26000926 2016
CUI: C0003165
Disease: Anthracosis
Anthracosis 		0.010 GeneticVariation disease BEFREE The present study is the first to have demonstrated an association between CYBA (rs7195830) polymorphism and the risk of developing CWP in subjects belong to the Han ethnic group in China and provides further clues for research into the pathogenesis of CWP. 30654669 2019
CUI: C3178782
Disease: Aortic Stiffness
Aortic Stiffness 		0.010 GeneticVariation phenotype BEFREE Common single nucleotide polymorphisms of the p22phox NADPH oxidase subunit do not influence aortic stiffness in young, healthy adults. 22995606 2013
CUI: C0852949
Disease: Arteriopathic disease
Arteriopathic disease 		0.010 GeneticVariation group BEFREE C242T polymorphism was determined by restriction fragment polymorphism (RFLP) analysis in 324 patients with documented PAOD and 295 control subjects without any known arterial disease. p22 phox 242 T allele frequencies and genotype distributions were not significantly different between patients and controls; the adjusted relative risk associated with the 242 T allele was 1.14 (95% CI 0.84-1.54, P=0.39), assuming an additive effect of the T allele. 10996353 2000
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 GeneticVariation disease BEFREE Some studies have identified a relationship between progression of atherosclerosis and C242T mutation in CYBA gene coding for p22phox, a subunit of the NADH/NADPH oxidase system. 16788250 2006
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 GeneticVariation disease BEFREE Endothelial function and atherosclerosis were examined by nitric oxide-related-products (NOx: NO2- and NO3-), O2-, endothelial NO synthase (eNOS), NADPH oxidase (p22phox), and ICAM1. 31266015 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 GeneticVariation disease BEFREE In this study, we enrolled 1746 type 2 diabetic subjects, determined 4 common genetic variants related to oxidative stress (glutamate-cysteine ligase modifier subunit (GCLM) C-588T, myeloperoxidase G-463A, human paraoxonase 1 Gln192Arg and NAD(P)H oxidase p22phox C242T polymorphisms), and measured carotid intima-media thickness (IMT) as a surrogate marker for atherosclerosis. 19126404 2009
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 GeneticVariation disease BEFREE The CYBA C242T polymorphism has been associated with cardiovascular phenotypes such as hypertension and atherosclerosis, but available data are conflicting. 22268370 2012
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 GeneticVariation disease BEFREE In healthy premenopausal women, the CYBA C242T polymorphism is an independent determinant of endothelial function and subclinical atherosclerosis of the carotid arteries. 29948131 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 GeneticVariation disease BEFREE Carriers of the CC genotype of the C242T p22 phox polymorphism (n = 44) revealed a significantly blunted endothelium-dependent dilator response (11 +/- 9.2% luminal area change vs 17 +/- 10%;P = 0.007), which was, by multivariate analysis, independent of other risk factors or atherosclerosis itself. 11133215 2001
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 GeneticVariation disease BEFREE The aim of the study was to analyze potential interactions between CYBA gene A640G polymorphism and traditional risk factors of atherosclerosis. 21777168 2011
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 GeneticVariation disease BEFREE These results show that the C242T mutation in the p22 phox gene is associated with progression of asymptomatic atherosclerosis in the subjects with type 2 diabetes and is also associated with insulin resistance in nondiabetic subjects. 12547880 2003
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 GeneticVariation disease BEFREE Polymorphisms of p22phox, an essential component of the NADPH oxidase system, are found to be associated with atherosclerosis, while a recent study found a significant association between the 214C>T polymorphism and the occurrence of ischemic cerebrovascular disease. 13130177 2003
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 AlteredExpression disease BEFREE Expression of gp91phox and p22phox mRNA was associated with the severity of atherosclerosis. gp91phox correlated with the plaque macrophage content, whereas Nox4 correlated with the content of alpha-actin-positive cells. 11914250 2002