|
Anthracosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The present study is the first to have demonstrated an association between CYBA (rs7195830) polymorphism and the risk of developing CWP in subjects belong to the Han ethnic group in China and provides further clues for research into the pathogenesis of CWP.
|
30654669 |
2019 |
|
Lung diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Coal workers' pneumoconiosis (CWP) is caused by long-term exposure to inhaled coal dust; it is likely influenced by the interaction between environmental factors and multiple susceptibility genes, such as the CYBA (cytochrome b-245α polypeptide) gene that has recently been identified to be involved in the genetic susceptibility for several pulmonary diseases.
|
30654669 |
2019 |
|
Status Epilepticus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The levels of MDA in plasma and Nox-4 and p22phox in the brain increased in SE rats, and the levels of SOD in plasma and Nrf-2, Ho-1 and sod1 in the brain decreased.
|
30983975 |
2019 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, differential expression of implantation and invasion-related molecules, such as cytochrome b-245 light chain (CYBA), neutrophil cytosol factor 2 (NCF2), Mitogen-activated protein kinase kinase kinase 4 (MAP3K4), matrix metalloproteinase 2 (MMP2), MMP9 and tumour necrosis factor α (TNF-α) might induce EED in both EEDT16 and EEDNC patients, although more severe dysfunction in the implantation and invasion ability of villous tissues was observed in EEDT16 patients.
|
30922443 |
2019 |
|
Refractory anemias
|
0.010 |
Biomarker
|
disease |
BEFREE |
On the other hand, immunoblot analysis revealed that co-treatment with RA and resveratrol caused remarkable accumulation of protein levels of gp91-phox (to 4-fold), p22-phox (to 5-fold) and p47-phox (to 4-fold) compared with those of the RA-treatment alone.
|
29183727 |
2018 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
On the other hand, immunoblot analysis revealed that co-treatment with RA and resveratrol caused remarkable accumulation of protein levels of gp91-phox (to 4-fold), p22-phox (to 5-fold) and p47-phox (to 4-fold) compared with those of the RA-treatment alone.
|
29183727 |
2018 |
|
Diabetic peripheral neuropathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We showed a strong association of the CYBA polymorphism rs4673 with DPN in Slovak children and adolescents with T1D.
|
29924645 |
2018 |
|
Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, there was no association of SNPs in the CYBA and NOX4 genes encoding the NADPH oxidase system proteins and the presence of NASH.
|
30087027 |
2018 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Differential resistance to platinum-based drugs and 5-fluorouracil in p22phox-overexpressing oral squamous cell carcinoma: Implications of alternative treatment strategies.
|
28498554 |
2017 |
|
Encephalomyelitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Active lesions in the marmoset EAE brain display increased expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (p22phox, p47phox, and gp91phox) and inducible nitric oxide synthase immunoreactivity within lesions with active inflammation and demyelination, coinciding with enhanced expression of mitochondrial heat-shock protein 70 and superoxide dismutase 1 and 2.
|
28505283 |
2017 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Furthermore, p22phox-dependent resistance to cisplatin, but not 5-FU, was demonstrated in mouse xenograft tumors.
|
28498554 |
2017 |
|
Malignant neoplasm of mouth
|
0.010 |
Biomarker
|
group |
BEFREE |
The p22phox expression may not only be a prognostic biomarker for prediction of chemotherapy outcomes, but the indication for alternative treatment strategies in oral cancer.
|
28498554 |
2017 |
|
Allergic asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We sought to characterize the involvement of NADPH oxidase in allergic asthma by studying the role of CYBA (p22phox) in human asthma and murine house dust mite (HDM)-induced allergic airway inflammation.
|
28510479 |
2017 |
|
Lip and Oral Cavity Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The p22phox expression may not only be a prognostic biomarker for prediction of chemotherapy outcomes, but the indication for alternative treatment strategies in oral cancer.
|
28498554 |
2017 |
|
Peroxisome Biogenesis Disorder, Complementation Group D
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The three CYBA variants (rs4673, rs1049254 and rs1049255) are benign: new evidence from a patient with CGD.
|
29132304 |
2017 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In accord with these results in the liver tissue, BLVRA mRNA levels in PBL were also significantly increased in HCC patients (p = 0.012). mRNA levels of NOX2 and p22phox in the liver tissue, although higher in HCC patients, did not differ significantly compared to control subjects (p > 0.05).
|
27740521 |
2017 |
|
Macroalbuminuric diabetic nephropathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The T allele carriers of p22phox C242T gene polymorphism might be predisposed to ODN.
|
27926811 |
2017 |
|
Tuberculosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our study found an association between the GA genotype of rs3794624 in CYBA with decreased tuberculosis susceptibility in two Chinese populations.
|
27901128 |
2016 |
|
Chronic glomerulonephritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in NADPH oxidase CYBA gene modify the risk of ESRD in patients with chronic glomerulonephritis.
|
26627442 |
2016 |
|
Alzheimer Disease, Late Onset
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of the p22phox polymorphism C242T with the risk of late-onset Alzheimer's disease in a northern Han Chinese population.
|
26000926 |
2016 |
|
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
The role of CYBA (p22phox) and catalase genetic polymorphisms and their possible epistatic interaction in cervical cancer.
|
25307973 |
2015 |
|
Hepatitis C
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
One hundred seventy eight naïve HCV patients (49.3% male; 65% HCV genotype 1) with positive HCV RNA were genotyped using specific primers and fluorescent-labeled probes for SNPs rs3017887 in NOX4 and -675 T → A in CYBA.
|
25888935 |
2015 |
|
Indian childhood cirrhosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Women with the C/T CYBA-242 genotype had a lower risk for ICC development (odds ratio (OR) = 0.515, 95% confidence interval (CI) 0.291-0.914, p = 0.023) whereas T/T CAT-262 genotype carriers present an increased risk for ICC (OR = 3.034, 95% CI 1.462-6.298, p = 0.003).
|
25307973 |
2015 |
|
Diabetic Polyneuropathies
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Association study of C936T polymorphism of the VEGF gene and the C242T polymorphism of the p22phox gene with diabetes mellitus type 2 and distal diabetic polyneuropathy.
|
26130419 |
2015 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The role of CYBA (p22phox) and catalase genetic polymorphisms and their possible epistatic interaction in cervical cancer.
|
25307973 |
2015 |