CYBB, cytochrome b-245 beta chain, 1536

N. diseases: 343; N. variants: 75
Disease: Cerebrovascular accident ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.050 Biomarker group BEFREE In conclusion, these findings demonstrate that Icariin attenuates cerebrovascular SMCs hyperplasia and subsequent remodeling through inhibiting Nox2-containing NADPH oxidase activation, suggesting Icariin may be a potential therapeutic agent to prevent the onset and progression of stroke. 30386989 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.050 Biomarker group BEFREE NOX2 and NOX4 overexpression is associated with aggravated ischemic injury, while NOX2/4-deficient mice had reduced stroke size. 29849881 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.050 Biomarker group BEFREE NOX2 and NOX4 may mediate HT in rats with large vessel stroke after mechanical reperfusion. 27075483 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.050 Biomarker group BEFREE While NOX2 appears to be a major source of pathological oxidative stress in the CNS, other NOX isoforms might also be of importance, for example, NOX4 in stroke. 24206089 2014
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.050 Biomarker group BEFREE Mechanisms contributing to cerebral infarct size after stroke: gender, reperfusion, T lymphocytes, and Nox2-derived superoxide. 20145655 2010