Lung Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Modulation of CYP1A1/CYP1A2 levels markedly reduced parent drug concentrations, significantly altering metabolite pharmacokinetics (PK) in humanized mice <i>in vivo</i><b>Conclusions:</b> We demonstrate that a P450 enzyme expressed in smokers' lungs and lung tumors has the capacity to metabolise osimertinib.
|
29437786 |
2018 |
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In adjacent histologically normal lung from lung cancer patients (n = 120), low levels of DNA methylation of the CYP1A1 enhancer were related to high levels of smoking-induced hydrophobic DNA adduct (p < 0.03), and to the presence of TP53 or K-ras mutations in the corresponding lung tumors (p < 0.03).
|
22213191 |
2012 |
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations.
|
18463401 |
2008 |
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
CYP1A1 *2B and *4 polymorphisms are associated with lung cancer susceptibility in Mexican patients.
|
18409147 |
2008 |
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women.
|
17980933 |
2008 |
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Interaction of cytochrome P4501A1 genotypes with other risk factors and susceptibility to lung cancer.
|
18082227 |
2008 |
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
CYP1A1 and GSTM1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis.
|
17900751 |
2008 |
Lung Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We also examined BaP-like DNA adducts, and CYP1A1 and DDH1 expression by immunohistochemistry in 120 lung tumors.
|
17163506 |
2007 |
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility.
|
17428572 |
2007 |
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Possible risk modification by CYP1A1, GSTM1 and GSTT1 gene polymorphisms in lung cancer susceptibility in a South Indian population.
|
16228113 |
2005 |
Lung Neoplasms
|
0.100 |
Biomarker
|
group |
LHGDN |
CYP1A1 polymorphisms and risk of lung cancer in non-smoking Chinese women: influence of environmental tobacco smoke exposure and GSTM1/T1 genetic variation.
|
15953982 |
2005 |
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Risk of non-small cell lung cancer and the cytochrome P4501A1 Ile462Val polymorphism.
|
15986113 |
2005 |
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
CYP1A1 and GSTM1 genetic polymorphisms in lung cancer populations exposed to arsenic in drinking water.
|
16012082 |
2005 |
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Metabolic gene polymorphisms and lung cancer risk in non-smokers. An update of the GSEC study.
|
16009381 |
2005 |
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes and lung cancer risk.
|
14534704 |
2004 |
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
CYP1A1 T3801 C polymorphism and lung cancer: a pooled analysis of 2451 cases and 3358 controls.
|
12594823 |
2003 |
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Previous studies from this and other laboratories have shown that treatment of pregnant mice with 3-methylcholanthrene (MC) caused lung tumors in the offspring, the incidence of which correlated with fetal inducibility of Cyp1a1.
|
9659583 |
1998 |
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In patients with inducible CYP1A1, the expressing GSTM1 gene appeared to have a protective effect against contracting bronchial lung cancer, since 88% (14/16) of the lung tumours in this patient group were peripheral, whereas almost equal numbers of peripheral and bronchial tumours were observed in those patients lacking the gene (P = 0.037).
|
8020145 |
1994 |