The frequency of each genotype of enzymes for detoxification, such as cytochrome P450-1A1 (CYP1A1), glutathione-S-transferase-pi (GST-pi), GST-mu and GST-theta, was analyzed in patients with unexplained recurrent miscarriage (number of miscarriages ≥3) by polymerase-chain reaction-restriction fragment length polymorphism.
The CYP1A1*2A polymorphism was found to have significant association with chronic obstructive pneumonopathy (p=0.045), peripheral circulatory problems (trend p=0.042), arteritis (p=0.022), allergies (trend p=0.046), hemorrhoids (trend p=0.026), allergic dermatitis (p=0.0016) and miscarriages (p=0.012).
The CYP1A1*2A polymorphism was found to have significant association with chronic obstructive pneumonopathy (p=0.045), peripheral circulatory problems (trend p=0.042), arteritis (p=0.022), allergies (trend p=0.046), hemorrhoids (trend p=0.026), allergic dermatitis (p=0.0016) and miscarriages (p=0.012).