|
Hyperoxia
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress.
|
24893714 |
2014 |
|
Diabetes Mellitus, Experimental
|
0.500 |
Biomarker
|
disease |
CTD_human |
Modulations of cytochrome P450 expression in diabetic mice by berberine.
|
22342832 |
2012 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
CTD_human |
Elevated blood pressure in cytochrome P4501A1 knockout mice is associated with reduced vasodilation to omega-3 polyunsaturated fatty acids.
|
22995157 |
2012 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
CTD_human |
Because TCDD induces cytochrome P4501A1 (CYP1A1) and CYP1A1 can increase ROS, we tested the hypothesis that TCDD-induced endothelial dysfunction and hypertension are mediated by CYP1A1.
|
20634294 |
2010 |
|
Male infertility
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Negative effects of serum p,p'-DDE on sperm parameters and modification by genetic polymorphisms.
|
19303595 |
2009 |
|
Malignant neoplasm of prostate
|
0.400 |
Biomarker
|
disease |
CTD_human |
In conclusion, our study demonstrated that exon 3 of mEH and CYP1A1 T/C gene polymorphism are predisposing risk factors for susceptibility of sporadic PCa in northern India.
|
17919073 |
2007 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
CTD_human |
Compared with women who had homozygous wild-type CYP1A1 m2 genotype, significantly increased risks of breast cancer were found for women with the CYP1A1 m2 homozygous variant genotype [odds ratio (OR) = 2.61, 95% confidence interval (CI): 1.00 - 6.80].
|
16792888 |
2006 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Compared with women who had homozygous wild-type CYP1A1 m2 genotype, significantly increased risks of breast cancer were found for women with the CYP1A1 m2 homozygous variant genotype [odds ratio (OR) = 2.61, 95% confidence interval (CI): 1.00 - 6.80].
|
16792888 |
2006 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
[Study on serum organochlorines pesticides (DDTs) level, CYP1A1 genetic polymorphism and risk of breast cancer: a case control study].
|
16792888 |
2006 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
We found that the risk of HCC was elevated in women harboring either heterozygous or homozygous variants of the CYP1A1 gene and the respective OR (and 95% confidence interval) were 6.61 (1.35, 32.43) and 12.00 (1.73, 83.46).
|
15341023 |
2004 |
|
Malignant neoplasm of prostate
|
0.400 |
Biomarker
|
disease |
CTD_human |
This study suggests that the CYP1A1 polymorphism and its combination with GSTM1 may be associated with PCa susceptibility in the Japanese population.
|
11275366 |
2001 |
|
Chronic Obstructive Airway Disease
|
0.370 |
Biomarker
|
disease |
CTD_human |
Relation of PON1 and CYP1A1 genetic polymorphisms to clinical findings in a cross-sectional study of a Greek rural population professionally exposed to pesticides.
|
19022366 |
2009 |
|
Prostatic Neoplasms
|
0.370 |
Biomarker
|
group |
CTD_human |
Cytochrome P4501A1 and microsomal epoxide hydrolase gene polymorphisms: gene-environment interaction and risk of prostate cancer.
|
17919073 |
2007 |
|
Prostatic Neoplasms
|
0.370 |
Biomarker
|
group |
CTD_human |
Genetic polymorphisms in cytochrome P450 (CYP) 1A1, CYP1A2, CYP2E1, glutathione S-transferase (GST) M1 and GSTT1 and susceptibility to prostate cancer in the Japanese population.
|
11275366 |
2001 |
|
Miscarriage
|
0.330 |
Biomarker
|
disease |
CTD_human |
Potential involvement of placental AhR in unexplained recurrent spontaneous abortion.
|
26593447 |
2016 |
|
Miscarriage
|
0.330 |
Biomarker
|
disease |
CTD_human |
The CYP1A1*2A polymorphism was found to have significant association with chronic obstructive pneumonopathy (p=0.045), peripheral circulatory problems (trend p=0.042), arteritis (p=0.022), allergies (trend p=0.046), hemorrhoids (trend p=0.026), allergic dermatitis (p=0.0016) and miscarriages (p=0.012).
|
19022366 |
2009 |
|
Hamartoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Hamartomas created a new compartment that concentrated TCDD up to 10-fold compared with serum and strongly expressed the TCDD-metabolizing enzyme cytochrome P450 1A1, thus representing a potentially significant source of enzymatic activity, which may add to the xenobiotic metabolism potential of the classical organs such as the liver.
|
21998131 |
2012 |
|
Depressive Symptoms
|
0.310 |
Biomarker
|
phenotype |
PSYGENET |
Among Caucasian women, those with the CYP1A1 rs2606345 CC and AC genotypes had approximately 2-fold greater odds of having depressive symptoms than did those with the AA genotype (95% confidence intervals [CIs], 1.33 to 4.66 and 1.25 to 3.14, respectively).
|
16949393 |
2006 |
|
Malignant neoplasm of kidney
|
0.310 |
Biomarker
|
disease |
CTD_human |
Somatic mutations in stilbene estrogen-induced Syrian hamster kidney tumors identified by DNA fingerprinting.
|
15003126 |
2004 |
|
Hepatomegaly
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models.
|
28108177 |
2017 |
|
Spontaneous abortion
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Potential involvement of placental AhR in unexplained recurrent spontaneous abortion.
|
26593447 |
2016 |
|
Abortion, Tubal
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Potential involvement of placental AhR in unexplained recurrent spontaneous abortion.
|
26593447 |
2016 |
|
Birth Weight
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study.
|
27592400 |
2016 |
|
Long QT Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
[Relationship of blood aryl hydrocarbon receptor mRNA and cytochrome P450 1A1 mRNA expression with corrected QT interval among residents exposed to arsenic via drinking water].
|
26988683 |
2016 |
|
Sinus Tachycardia
|
0.300 |
Biomarker
|
disease |
CTD_human |
CYP1A1 mRNA expression level was significantly higher in residents with sinus tachycardia or bradycardia than in residents with normal heart rate (1.47×10(-3)(0.87×10(-3), 2.77×10(-3)) vs.1.24×10(-3)(0.64×10(-3), 2.31×10(-3)), P<0.05).
|
26988683 |
2016 |