|
Acrania
|
0.300 |
Biomarker
|
disease |
CTD_human |
Caffeine, selected metabolic gene variants, and risk for neural tube defects.
|
20641098 |
2010 |
|
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
In this study, we examined the effect of CYP1A2 activity using a urinary caffeine metabolic ratio assay for 54 Chinese women with newly diagnosed lung cancer (including 28 adenocarcinomas) and 174 hospital controls.
|
11285205 |
2001 |
|
Adenocarcinoma
|
0.030 |
Biomarker
|
group |
BEFREE |
This study suggests that SNPs of CYP1A2 could be considered as promising biomarkers in the aetiology of lung AD in smokers.
|
19332078 |
2009 |
|
Adenocarcinoma
|
0.030 |
GeneticVariation
|
group |
BEFREE |
A significant interaction between CYP1A2-T/delT or delT/delT genotypes and tobacco consumption (pack-years) adjusted for age was evident (OR (95% CI) 7.78 (1.52-42.8)) in the SCC cases who smoked relatively less (< or =33 pack-years, I quartile value), but not in adenocarcinoma and controls.
|
17509724 |
2007 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
When the combined NAT2/CYP1A2 status was examined, women with slow NAT2 and rapid CYP1A2 activity were at highest risk (adjusted OR 6.9, 95% CI 1.3-37.6) relative to women with rapid NAT2 and slow CYP1A2 activity, for lung adenocarcinoma.
|
11285205 |
2001 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
CYP1A2 genetic polymorphisms and adenocarcinoma lung cancer risk in the Tunisian population.
|
19332078 |
2009 |
|
Adenocarcinoma of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
To test the hypothesis that genetic variation in the metabolism of tobacco carcinogens, such as aromatic amines (AA) and heterocyclic amines (HCA), contributes to pancreatic cancer, we have examined genetic polymorphisms of three key enzymes, i.e. cytochrome P450 1A2 (CYP1A2) and N-acetyltransferase 1 and 2 (NAT1 and NAT2), in a hospital-based case-control study of 365 patients with pancreatic adenocarcinoma and 379 frequency-matched healthy controls.
|
15987714 |
2006 |
|
Adenoma
|
0.020 |
GeneticVariation
|
group |
BEFREE |
In contrast, NAT2 genotype and CYP1A2 and NAT2 hepatic activity measured by caffeine urinary metabolites were not associated with adenoma risk, although an increase in risk with rapid CYP1A2 activity could not be ruled out (OR = 1.46; 95% CI 0.76-2.81).
|
11875368 |
2002 |
|
Adenoma
|
0.020 |
GeneticVariation
|
group |
BEFREE |
One hundred and ninety-eight CRC cases, 422 adenomas (206 low-risk and 216 high-risk adenomas) and 222 controls were genotyped for the CYP1A2 164 A-->C polymorphism and questionnaires were used to assess environmental exposure.
|
18751408 |
2008 |
|
Adenoma of large intestine
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Significant associations were found between the CYP1A2-164A-->C polymorphism (CYP1A2*1F) and the risk of colorectal adenomas, suggesting that the studied polymorphism plays an important role in CRC risk in humans.
|
16157215 |
2005 |
|
Adenoma of large intestine
|
0.030 |
Biomarker
|
disease |
BEFREE |
Heterocyclic amine intake, smoking, cytochrome P450 1A2 and N-acetylation phenotypes, and risk of colorectal adenoma in a multiethnic population.
|
22628494 |
2013 |
|
Adenoma of large intestine
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
CYP1A2 164 A-->C polymorphism, cigarette smoking, consumption of well-done red meat and risk of developing colorectal adenomas and carcinomas.
|
18751408 |
2008 |
|
Adverse reaction to drug
|
0.300 |
Biomarker
|
group |
CTD_human |
Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice.
|
10445756 |
1999 |
|
Age related macular degeneration
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The CYP1A2 (-163C>A) Rs762551 C/A genotype was more frequently documented in the control group compared with patients with age-related macular degeneration (46.3% vs. 30.7%, p = 0.002) and was associated with a decreased risk of having age-related macular degeneration (OR = 0.580.
|
28095090 |
2017 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
The AD susceptibility gene cholesterol 25-hydroxylase (<i>CH25H</i>) is upregulated in the AD brain and is involved in the antiviral immune response.
|
29559905 |
2018 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease.
|
16909003 |
2005 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to determine whether the polymorphisms of the CYP1A2 and the CYP1A1 genes in ALS patients are associated with riluzole metabolic profiles.
|
17852022 |
2007 |
|
Antley-Bixler Syndrome, Autosomal Dominant
|
0.010 |
Biomarker
|
disease |
BEFREE |
Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase.
|
18455494 |
2008 |
|
Anxiety
|
0.010 |
Biomarker
|
disease |
BEFREE |
CYP1A2 is responsible for the majority of the metabolism of caffeine, and ADORA2A has been linked to caffeine-induced anxiety.
|
30248915 |
2018 |
|
Anxiety Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
CYP1A2 is responsible for the majority of the metabolism of caffeine, and ADORA2A has been linked to caffeine-induced anxiety.
|
30248915 |
2018 |
|
Aortic Valve Insufficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
CYP1A2 rs762551 was identified as a new potential predictive marker for early breast cancer events in AI-treated breast cancer patients.
|
27029552 |
2016 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
CYPIA2 metabolism as measured by the median ratio of (1,7-dimethylxanthine + 1,7-dimethyluric acid)/caffeine was significantly induced by smoking in both patients with atherosclerosis (ratio of 6.5 in nonsmokers and 12.4 in smokers; p < 0.05) and control subjects (ratio of 8.2 in nonsmokers and 14.8 in smokers; p < 0.05), but values in atherosclerotic and control nonsmokers and smokers were similar.
|
8375127 |
1993 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility.
|
28794002 |
2017 |
|
Asthma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the effect of genetic polymorphisms in the 5'-flanking region to the first intron of the CYP1A2 gene on theophylline metabolism in 75 Japanese patients with asthma and 159 healthy Japanese volunteers.
|
12732846 |
2003 |
|
Asthma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Gene mutations that are known to alter the response to asthma therapy include Arg/Arg atr position 16, mutations of LTC4S, ALOX5, and GR/NR3C1, increased expression of GR , CRHR1 variants, and mutations in CYP1A2 (-22964 [G/A]), and T 314 allele for histamine N-methyltransferase.
|
17672811 |
2007 |