|
Marijuana Abuse
|
0.010 |
Biomarker
|
disease |
BEFREE |
Medications that are prominent substrates for CYP2C19, CYP2C9, and CYP1A2 may be particularly at risk of altered disposition by concomitant use of cannabis or 1 or more of its constituents.
|
31433338 |
2020 |
|
Thyroid Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Cytochrome P450 1A2 activity and incidence of thyroid disease and cancer after chronic or acute exposure to dioxins.
|
31608602 |
2020 |
|
Hepatoblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HepG2-1A2 C2 and C7: Lentivirus vector-mediated stable and functional overexpression of cytochrome P450 1A2 in human hepatoblastoma cells.
|
31706005 |
2020 |
|
Slow acetylator due to N-acetyltransferase enzyme variant
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To better understand the role of NAT2 genetic polymorphism in ABP- and AF-induced mutagenesis and DNA damage, nucleotide excision repair-deficient (UV5) Chinese hamster ovary (CHO) cells were stably transfected with human CYP1A2 and either NAT2*4 (rapid acetylator) or NAT2*5B (slow acetylator) alleles.
|
31490564 |
2020 |
|
Fatty Liver, Alcoholic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression and activity of Cytochrome P450 1A2 (CYP1A2) is significantly increased in alcoholic fatty liver according to our previous studies.
|
30979496 |
2019 |
|
Rabies (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cholesterol 25-hydroxylase suppresses rabies virus infection by inhibiting viral entry.
|
31552533 |
2019 |
|
Hepatocellular Adenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We here show that hepatocellular adenomas but not hepatocellular carcinomas or colorectal liver metastasis contain significant residual CYP1A2 activity.
|
30869529 |
2019 |
|
Gastrointestinal Stromal Tumors
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Genetic polymorphisms in ABCG2 and CYP1A2 are associated with imatinib dose reduction in patients treated for gastrointestinal stromal tumors.
|
30713339 |
2019 |
|
MRSA - Methicillin resistant Staphylococcus aureus infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
On day 7, mRNA expression of Cyp1a2, 2d22, and 3a11 were decreased by the high level of MRSA, but the low level of MRSA increased their expressions.
|
30944282 |
2019 |
|
Chronic small plaque psoriasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with moderate to severe chronic plaque psoriasis (n = 21) received single oral doses of sensitive probe substrates for CYP1A2 (caffeine 100 mg), CYP2C9 (warfarin 10 mg), CYP2C19 (omeprazole 20 mg), CYP2D6 (metoprolol 50 mg), and CYP3A (midazolam 2 mg) on day 1, followed by 12 weeks of subcutaneous risankizumab treatment of 150 mg once every 4 weeks from day 8 to day 92, and again the same cocktail of substrates on day 98.
|
30574672 |
2019 |
|
Secondary malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The CYP1A2 activity analysis of neoplastic lesions and adjacent nontumor liver tissue from resected tumor specimens revealed a significantly higher CYP1A2 activity (median, interquartile range) in nontumor tissues (35.5, 15.9-54.4 µU/mg) compared with hepatocellular adenomas (7.35, 1.2-32.5 µU/mg), hepatocellular carcinomas (0.18, 0.0-2.0 µU/mg), or colorectal liver metastasis (0.17, 0.0-2.1 µU/mg).
|
30869529 |
2019 |
|
Renal Insufficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Then, the model was then adapted to a cUTI paediatric population according to the degree of renal impairment (KF) affecting renal clearance (CL<sub>Renal,</sub>) and CYP1A2 clearance (CL<sub>CYP1A2</sub>).
|
30503378 |
2019 |
|
Complicated urinary tract infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Then, the model was then adapted to a cUTI paediatric population according to the degree of renal impairment (KF) affecting renal clearance (CL<sub>Renal,</sub>) and CYP1A2 clearance (CL<sub>CYP1A2</sub>).
|
30503378 |
2019 |
|
Refractory anemias
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
An mRNA expression analysis revealed that CYP1A2 and CYP2E1 levels were decreased while those of NQO1, GPx, and GSTm1 increased after S. fruticosa and RA treatments.
|
28718679 |
2018 |
|
Anxiety
|
0.010 |
Biomarker
|
disease |
BEFREE |
CYP1A2 is responsible for the majority of the metabolism of caffeine, and ADORA2A has been linked to caffeine-induced anxiety.
|
30248915 |
2018 |
|
Anxiety Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
CYP1A2 is responsible for the majority of the metabolism of caffeine, and ADORA2A has been linked to caffeine-induced anxiety.
|
30248915 |
2018 |
|
Atrial Fibrillation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Age, chronic pulmonary disease, history of heart failure and of coronary artery disease, and systolic blood pressure - but not the genotype or the caffeine × CYP1A2 interaction term - were significant confounders of the association between incident atrial fibrillation and being in the third tertile of caffeine intake (hazard ratio 0.249, 95% confidence intervals 0.161-0.458, P < 0.01).
|
29692210 |
2018 |
|
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Our previous studies found allelic differences in the aryl hydrocarbon receptor and cytochrome P450 1A2 (CYP1A2) affect sensitivity to developmental PCB exposure, resulting in cognitive deficits and motor dysfunction.
|
29197979 |
2018 |
|
Diabetes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The present work firstly reported that Hon treatment ameliorated the abnormal change of hepatic CYP activity (including CYP2E1, CYP4A and CYP1A2) and the transporter mRNA expression (including hepatic Oat2 and Oatp2b1, renal Bcrp and Mrp4) in type 2 diabetic rats induced by high-fat diet and strepotozotocin, which are associated with the occurrence and development of diabetes.
|
29534510 |
2018 |
|
Diabetes Mellitus
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The present work firstly reported that Hon treatment ameliorated the abnormal change of hepatic CYP activity (including CYP2E1, CYP4A and CYP1A2) and the transporter mRNA expression (including hepatic Oat2 and Oatp2b1, renal Bcrp and Mrp4) in type 2 diabetic rats induced by high-fat diet and strepotozotocin, which are associated with the occurrence and development of diabetes.
|
29534510 |
2018 |
|
nervous system disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders.
|
29197979 |
2018 |
|
Reoviridae Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection.
|
29950420 |
2018 |
|
Sleep Apnea Syndromes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to evaluate the effect of CIH on the expression of hepatic CYP1A2 in a mouse model with sleep apnea.
|
29607154 |
2018 |
|
Memory impairment
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In our previous studies, we found that high-affinity Ahr<sup>b</sup>Cyp1a2(-/-) and poor-affinity Ahr<sup>d</sup>Cyp1a2(-/-) knockout mice were most susceptible to learning and memory deficits following developmental PCB exposure compared with Ahr<sup>b</sup>Cyp1a2(+/+) wild type mice (C57BL/6J strain).
|
29409959 |
2018 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The study indicates that CYP1A2*1F polymorphism is associated with ESCC risk and the risk is modified in salt drinkers.
|
29278931 |
2018 |