Disease: Hypertensive disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.050 GeneticVariation group BEFREE However, increased risk of myocardial infarction and hypertension has been suggested for individuals who carry a functional variant at cytochrome P450 1A2 (CYP1A2), which makes them less effective at metabolizing caffeine. 30838377 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.050 Biomarker group BEFREE However, Csk siRNA only increased blood pressure while Ulk3 and Cyp1a2 siRNA did not change it. 26751575 2016
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.050 GeneticVariation group BEFREE These data show that coffee consumption increases the risk of impaired fasting glucose in hypertension particularly among carriers of the slow CYP1A2 *1F allele. 25595320 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.050 GeneticVariation group BEFREE CYP1A2 variants were associated with hypertension in non-smokers, but not in smokers (CYP1A2-smoking interaction P = 0.01). 22492992 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.050 GeneticVariation group BEFREE The aim of the present study was to investigate the effect of coffee intake on the risk of developing hypertension needing antihypertensive treatment in individuals stratified by CYP1A2 genotype. 19451835 2009