Tardive Dyskinesia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of covariance (ANCOVA) with age, sex, duration of disease, chlorpromazine equivalent (CPZEQ) incorporated as covariates showed that limb-truncal, but not orofacial TD, is associated with CYP1A2 (-163C>, rs762551) polymorphism (F = 3.27, P = 0.039).
|
25602162 |
2015 |
Tardive Dyskinesia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Search for these determinants has led to a few consensus associations of CYP2D6 *10, CYP1A2*1F, DRD2 Taq1A (rs1800497), DRD3 rs6280" genes_norm="1814">Ser9Gly (rs6280) and MnSOD Ala9Val (rs4880) variants with TD.
|
18781856 |
2008 |
Tardive Dyskinesia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We further investigated whether the CYP1A2 1545 C>T polymorphism has any role to play in susceptibility to TD and in schizophrenia per se.
|
16969362 |
2007 |
Tardive Dyskinesia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The genotype and allele frequencies of HTR2A and CYP1A2 gene were similar in schizophrenia with TD, schizophrenia without TD, and healthy controls.
|
17688403 |
2007 |
Tardive Dyskinesia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An association between TD and the CYP2D6 100T and CYP1A2 163C alleles was observed.
|
16490169 |
2006 |
Tardive Dyskinesia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we have investigated the significance of CYP1A2 gene polymorphisms in TD susceptibility among chronic schizophrenia sufferers (n=335) from north India.
|
15505641 |
2005 |
Tardive Dyskinesia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We did not find significant associations between the 734C/A and -2964G/A polymorphisms of CYP1A2 gene and TD in Japanese patients with schizophrenia.
|
15564895 |
2004 |
Tardive Dyskinesia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Consistent with other studies, the prevalence of TD was significantly higher among smokers than non-smokers; however, we did not find an association between the C --> A genetic polymorphism of CYP1A2 and TD.
|
12790158 |
2003 |
Tardive Dyskinesia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The antipsychotic adverse reaction of tardive dyskinesia and its association with the dopamine D(3) receptor will be critically examined, as well as the added influence of antipsychotic metabolism via the cytochrome P450 1A2 gene (CYP1A2 ).
|
12351588 |
2002 |
Tardive Dyskinesia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, our results do not support the hypothesis that the C-->A polymorphism in the CYP1A2 gene is involved in the etiology of TD in the German population.
|
11496364 |
2001 |
Tardive Dyskinesia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The studies presented in this article evaluate the role of single nucleotide polymorphisms in dopamine D3 receptor (DRD3) and CYP1A2 genes for propensity to develop TD in patients with schizophrenia.
|
11179771 |
2001 |
Tardive Dyskinesia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 85 patients with schizophrenia were assessed for TD severity using the Abnormal Involuntary Movement Scale (AIMS), and were subsequently genotyped for the (C-->A) polymorphism in CYP1A2.
|
10889552 |
2000 |