Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
Given that a slower CYP2A6 metabolism has been associated with less vulnerability to develop nicotine dependence, the current studies sought to validate a novel CYP2A6 inhibitor, (5-(4-ethylpyridin-3-yl)thiophen-2-yl)methanamine (DLCI-1), for its effects on intravenous nicotine self-administration.
|
31628204 |
2020 |
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
CTD_human |
The Value of Biosamples in Smoking Cessation Trials: A Review of Genetic, Metabolomic, and Epigenetic Findings.
|
28472521 |
2018 |
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, we evaluated the possible association between SNPs in CYP2A6 with cigarette smoking and nicotine addiction-related variables in Mexican mestizo smokers.
|
28734893 |
2017 |
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because the CYP2A6 effect was seen only in smokers, these data suggest that the rate of nicotine metabolism-and thus the concentration of nicotine presented to the brain over the course of nicotine addiction-shapes brain circuits that, among other functions, compute reward and impulsivity processes.
|
27865452 |
2017 |
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Distribution of polymorphic variants of CYP2A6 and their involvement in nicotine addiction.
|
28507465 |
2017 |
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study sought to identify time-dependent within-participant effects of CYP2A6 genotypes on smoking frequency and nicotine dependence in young smokers.
|
25744963 |
2016 |
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
CTD_human |
Variation in CYP2A6 and tobacco dependence throughout adolescence and in young adult smokers.
|
26644138 |
2016 |
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
For nicotine and metabolite levels, function of the cytochrome P450 2A6 liver enzyme, which can be assessed with the nicotine metabolite ratio or via genotype, has been found to predict response, with slow nicotine metabolizers having less severe nicotine dependence and a greater likelihood of quitting with NRT than normal metabolizers.
|
25895022 |
2015 |
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study investigated whether polymorphisms of the ankyrin repeat and kinase domain containing 1 gene (ANKK1), which is adjacent to the dopamine D2 receptor gene (DRD2), and the dopamine transporter (SLC6A3) and cytochrome P450 2A6 (CYP2A6) genes influence smoking cessation and nicotine dependence in a Japanese population.
|
25526961 |
2014 |
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
CYP2A6 genotype is not associated with nicotine dependence, as defined by the Fagerström Test of Nicotine Dependence, demonstrating that cigarettes smoked per day (CPD) and nicotine dependence have distinct genetic correlates.
|
22451501 |
2012 |
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
CTD_human |
CYP2A6 and CYP2B6 genetic variation and its association with nicotine metabolism in South Western Alaska Native people.
|
22569203 |
2012 |
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found a significant genotype effect (all P≤0.017) for the following smoking-related phenotypes: (i) cigarettes smoked per day and CYP2A13*3; (ii) pack years smoked and CYP2A6*2, CYP2A6*1×2, CYP2A13*7, CYP2B6*4 and DRD2-ANKK1 2137G>A (Taq1A); (iii) nicotine dependence (assessed with the Fagestrom test) and CYP2A6*9.
|
22046326 |
2011 |
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cigarette consumption (P < .001) and nicotine dependence (P = .036) were the highest in the combined CYP2A6 normal metabolizers and CHRNA5-A3-B4 AA (tag single-nucleotide polymorphism rs1051730 G>A) risk group.
|
21747048 |
2011 |
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
Among the genes at the two newly associated loci are genes encoding nicotine-metabolizing enzymes (CYP2A6 and CYP2B6) and nicotinic acetylcholine receptor subunits (CHRNB3 and CHRNA6), all of which have been highlighted in previous studies of smoking and nicotine dependence.
|
20418888 |
2010 |
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
The psychoactive compound responsible for tobacco addiction, nicotine and the potent carcinogens present at high concentrations either in cigarette mainstream smoke or in smokeless tobacco products, 4-(methylnitrosamino)-1-(3-pyridyl)-butanone (NNK) and N-nitrosonornicotine (NNN) can be metabolized by CYP2A6.
|
19018727 |
2008 |
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Initial smoking experiences did not account for how CYP2A6 genetic variation impacts nicotine dependence.
|
17130279 |
2007 |
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We performed a survey on the relationship between nicotine dependence and psychological (the personality traits using neuroticism extroversion openess-five factor inventory (NEO-FFI)/nicotine metabolism (the CYP2A6 gene polymorphism) factors among Japanese young students to elucidate the mechanism of the development of nicotine dependence.
|
17934923 |
2007 |
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
CTD_human |
Smoking cessation program and CYP2A6 polymorphism.
|
16720336 |
2006 |
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Collectively, CYP2A6 genotypes are related with nicotine dependence, influencing smoking habits and withdrawal symptoms in quitting smoking.
|
16402086 |
2006 |
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence.
|
15735609 |
2005 |
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
CTD_human |
Case control studies in adults suggest that defective alleles in the gene that codes for the hepatic cytochrome P450 2A6 (CYP2A6) protect against nicotine dependence (ND) and higher levels of cigarette consumption.
|
15564629 |
2004 |
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
Case control studies in adults suggest that defective alleles in the gene that codes for the hepatic cytochrome P450 2A6 (CYP2A6) protect against nicotine dependence (ND) and higher levels of cigarette consumption.
|
15564629 |
2004 |
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Further research is needed in order to improve our understanding of how genetic variation in CYP2A6 alters the risk for nicotine dependence and lowers nicotine consumption.
|
11768189 |
1999 |
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among Caucasians, an additional defective and frequently distributed allele (CYP2A6*3) has been suggested to play a protective role against nicotine addiction and cigarette consumption.
|
10544257 |
1999 |