GRK2, G protein-coupled receptor kinase 2, 156

N. diseases: 159; N. variants: 2
Disease: Hyperaldosteronism ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020428
Disease: Hyperaldosteronism
Hyperaldosteronism 		0.020 AlteredExpression disease BEFREE Our study reveals that GRK2 activity is a critical player downstream of the aldosterone signaling pathway; therefore, inhibiting this kinase is an attractive strategy to prevent the cardiac structural disarray and dysfunction that accompany any clinical condition accompanied by hyperaldosteronism. 31447681 2019
CUI: C0020428
Disease: Hyperaldosteronism
Hyperaldosteronism 		0.020 Biomarker disease BEFREE Most importantly, we show that ventricular dysfunction caused by chronic hyper-aldosteronism in vivo is completely prevented in cardiac Grk2 knockout mice (KO) and to a lesser extent in Grk5 KO mice. 26932512 2016