GRK2, G protein-coupled receptor kinase 2, 156

N. diseases: 159; N. variants: 2
Disease: Tongue Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0040411
Disease: Tongue Neoplasms
Tongue Neoplasms 		0.010 AlteredExpression group BEFREE We uncover that G-protein-coupled receptor kinase-2 (GRK2) expression is reduced in undifferentiated, high-grade human HNSCC tumors, whereas its silencing in model human HNSCC cells is sufficient to trigger epithelial-to-mesenchymal transition (EMT) phenotypic features, an EMT-like transcriptional program and enhanced lymph node colonization from orthotopic tongue tumors in mice. 31850518 2019