GRK2, G protein-coupled receptor kinase 2, 156

N. diseases: 159; N. variants: 2
Disease: Endothelial dysfunction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.040 Biomarker phenotype BEFREE The purpose of this study was to investigate the combined effect of an antihypertensive drug (clonidine) and a G-protein-coupled receptor kinase 2 (GRK2) inhibitor on rebound hypertension and endothelial dysfunction. 29463871 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.040 AlteredExpression phenotype BEFREE It has been demonstrated that G protein-coupled receptor kinase 2 (GRK2) overexpression contributes to diabetic endothelial dysfunction and oxidative stress, which also underlies ED in T2DM. 30226217 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.040 Biomarker phenotype BEFREE Liver-targeting GRK2 siRNA delivery represents a novel therapeutic tool to restore glucose homeostasis and reduce endothelial dysfunction. 28814745 2017
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.040 Biomarker phenotype BEFREE We tested the hypothesis that GRK2 may be an important contributor to vascular endothelial dysfunction in diabetes. 24570070 2014