Disease: Central nervous system depression (disorder) ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0151559
Disease: Central nervous system depression (disorder)
Central nervous system depression (disorder) 		0.020 GeneticVariation disease BEFREE We aimed to discover the genetic markers predictive of codeine toxicity by evaluating the associations between polymorphisms in cytochrome P450 2D6 (CYP2D6), UDP-glucuronosyltransferase 2B7 (UGT2B7), P-glycoprotein (ABCB1), mu-opioid receptor (OPRM1), and catechol O-methyltransferase (COMT) genes, which are involved in the codeine pathway, and the symptoms of CNS depression in 111 breastfeeding mothers using codeine and their infants. 22398969 2012
CUI: C0151559
Disease: Central nervous system depression (disorder)
Central nervous system depression (disorder) 		0.020 Biomarker disease BEFREE Breastfed infants of mothers who are CYP2D6 UMs combined with the UGT2B7*2/*2 are at increased risk of potentially life-threatening CNS depression. 18719619 2009