|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To explore the genetic effect of rs2031920 and rs3813867 polymorphisms within the cytochrome P450 2E1 (<i>CYP2E1</i>) gene on the risk of squamous cell carcinoma (SCC), a meta-analysis was performed.
|
29743817 |
2018 |
|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to investigate the associations between ADH1C and CYP2E1 gene polymorphisms with oral squamous cell carcinoma in an ethnically homogeneous Caucasian population.
|
21705789 |
2011 |
|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
CYP2E1 (*c1/*c1), ALDH2 (*1/*2) and ADH1B (*1/*1) genotype frequencies were higher among patients with squamous cell carcinomas, at a level close to statistical significance (P=0.014; P=0.094; P=0.0001 respectively).
|
18322963 |
2008 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CYP2C8, CYP3A4, CYP3A5, and CYP2E1) between SCC patients and healthy subjects and may contribute to the development of SCC in the esophagus.
|
17373732 |
2007 |
|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Association of combined CYP2E1 gene polymorphism with the risk for esophageal squamous cell carcinoma in Huai'an population, China.
|
18028774 |
2007 |
|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the promoter region of the Cytochrome P4502E1 (CYP2E1) gene reportedly modify the metabolic activity of CYP2E1 enzyme, and have been associated with increased susceptibility to squamous cell carcinoma (SCC) of the oesophagus in high prevalence areas such as China.
|
17264406 |
2006 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in the selected genes controlling carcinogen metabolism (CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1, GSTT1) considered separately or in different combinations, were investigated for an association with tobacco smoke-associated squamous cell carcinoma (SCC) of the larynx.
|
15914211 |
2005 |
|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In comparing patients with controls, the heterozygous CYP2E1*6 genotype was associated with increased risk of the development of squamous cell carcinoma of the oesophagus (odds ratio, 5.90; p < 0.001) after adjusting for age, sex, smoking and alcohol consumption.
|
15899651 |
2005 |
|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of cytochrome P450 2E1 polymorphisms and head and neck squamous cell cancer.
|
15177663 |
2004 |
|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, we have examined, in patients with one squamous cell carcinoma (SCC) of the head and neck, associations between GSTM1, GSTT1, GSTM3, GSTP1, CYP2D6, CYP1A1, CYP2E1, and CCND1 genotypes and the outcome parameters, tumor extension, histological grade, and presence of nodes.
|
10498401 |
1999 |
|
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In agreement with past experimental and epidemiological data, the associations found in this study between CYP1A1 and lung SCC and between CYP2E1 and lung AC suggest a certain specificity of tobacco smoke PAHs for lung SCC and tobacco-specific nitrosamines for lung ACs.
|
9809991 |
1998 |
|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is suggested that C type of CYP2E1 may define individuals at an increased risk of squamous cell carcinoma through the impaired metabolism of a certain carcinogen which predisposes to p53 gene mutation.
|
9066584 |
1997 |
|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the genetic polymorphisms of CYP1A1, CYP2E1 and GSTM1 in Japanese esophageal cancer patients (n = 53) with a histological diagnosis of squamous-cell carcinoma, to determine whether susceptibility to esophageal cancer is associated with these polymorphisms.
|
9139841 |
1997 |