|
Adrenoleukodystrophy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Patients with ALD have reduced MATα1 levels and a decrease in methylated/total CYP2E1 ratio.
|
31077594 |
2019 |
|
Adrenoleukodystrophy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our aim is to examine whether SUMOylation could regulate ethanol-induced CYP2E1 expression in ALD and to elucidate the molecular mechanism(s).
|
29401608 |
2018 |
|
Adrenoleukodystrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to investigate CYP2E1 induction in ALD, and its correlation with oxidative DNA lesions and with hepatic histology.
|
29120493 |
2018 |
|
Adrenoleukodystrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unlike CYP2E1, CYP2A5 protects against the development of ALD.
|
29637855 |
2018 |
|
Adrenoleukodystrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fourteen markers were genotyped within two alcohol metabolism genes [Alcohol dehydrogenase (ADH) gene clusters (ADH1B and ADH1C) and Aldehyde dehydrogenase (ALDH2)], one microsomal ethanol oxidizing enzyme cytochrome p450 (CYP2E1) and three oxidative stress response (OSR) genes (MnSOD, GSTT1 and GSTM1) among 490 Bengali individuals (322 ALD and 168 control) from Eastern and North-Eastern India and validation was performed in a new cohort of 150 Bengali patients including 100 ALD and 50 advanced non-alcoholic steatohepatitis (NASH).
|
26937962 |
2016 |
|
Adrenoleukodystrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The review is focused on genetic polymorphisms of alcohol metabolizing enzymes and the role of cytochrome p450 2E1 and iron in ALD.
|
26342547 |
2015 |
|
Adrenoleukodystrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The presentations are focused on genetic polymorphisms of ethanol metabolizing enzymes and the role of cytochrome P4502E1 (CYP2E1) in ALD.
|
24816574 |
2015 |
|
Adrenoleukodystrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together our data support a novel Cyp2e1-circadian clock protein mechanism for alcohol-induced gut leakiness that could provide new avenues for therapy of ALD.
|
25462064 |
2014 |
|
Adrenoleukodystrophy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Significant associations between CYP2E1 Pst I/Rsa I polymorphism and ALD risk were also observed in Asians (c2c2 vs. c1c1: OR = 4.11, 95%CI 2.32-7.29) and in Caucasians (c2c2/c1c2 vs. c1c1: OR = 1.58, 95%CI 1.04-2.42) when ALD patients were compared with alcoholics without ALD.
|
23335995 |
2013 |
|
Adrenoleukodystrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that both CYP2E1 and ethanol induce ATF4 and the integrated stress response, a pathway which coordinates signals from multiple stresses, as well as established risk factors for ALD, and can display detrimental cellular effects upon prolonged activation.
|
21146245 |
2011 |
|
Adrenoleukodystrophy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Regardless of nationality, patients who carried the rare CYPIIE1 C2 and GSTP1 Val alleles were at higher risk of ALD.
|
19357030 |
2009 |
|
Adrenoleukodystrophy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ALD patients with concomitant anti-HER IgG and the CTLA-4 G allele had a 22-fold higher (OR: 22.9 [4.2-125.6]) risk of developing anti-CYP2E1 autoreactivity than subjects negative for these factors.
|
12540792 |
2003 |
|
Adrenoleukodystrophy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Both heterozygosity for allele C2 of CYP2E1 and homozygosity for allele ADH3*2 of ADH3 are independent risk factors for ALD in alcohol abusers.
|
11471570 |
2001 |
|
Adrenoleukodystrophy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, our results suggest that the allelic variations at the CYP2E1 gene locus also do not significantly affect the development of alcoholism or ALD in Han Chinese and Atayal natives of Taiwan.
|
8651460 |
1996 |
|
Adrenoleukodystrophy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The findings indicate that Caucasians carrying the Rsa I c2 allele of the CYP2E1 gene may be at higher risk of developing ALD if they abuse alcohol.
|
8747406 |
1995 |