|
Malignant neoplasm of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The cytochrome P4501A1 (<i>CYP1A1)</i> rs4646903 T>C polymorphism increased GCC risk, the cytochrome P4502E1 (<i>CYP2E1)</i> rs2031920 C>T polymorphism increased EC risk, while the <i>GSTM1</i> null genotype decreased EC risk.
|
31423187 |
2019 |
|
Malignant neoplasm of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that AG genotype of CYP1A1 in Chaoshan area and GG (CC) genotype of CYP2E1 in Taihang area are significantly associated with esophageal cancer susceptibility.
|
22088806 |
2012 |
|
Malignant neoplasm of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CYP2E1 Rsa I/Pst I polymorphism and esophageal cancer risk: a meta-analysis based on 1,088 cases and 2,238 controls.
|
20195803 |
2011 |
|
Malignant neoplasm of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A case-control study was performed in 135 EC patients and 195 healthy controls to analyze association of polymorphisms in glutathione S-transferase (GST) mu (GSTM1), GST theta (GSTT1), GST pi (GSTP1), GSTM3, Cytochrome P450 (CYP)1A1, and CYP2E1 genes with susceptibility to EC as well as their interaction with environmental factors such as smoking and high consumption of salted tea in Kashmir valley.
|
20661821 |
2010 |
|
Malignant neoplasm of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population.
|
17916905 |
2007 |
|
Malignant neoplasm of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To assess the actual influence of ADH2 Arg47His, ALDH2 Glu487Lys and CYP2E1 variant c2 allele polymorphisms on esophageal cancer risk with conjunction with alcoholic consumption, the present 1:3 matched case-control study was conducted.
|
16235983 |
2005 |
|
Malignant neoplasm of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In summary, our case-control study of oesophageal cancer revealed an elevated risk associated with the CYP2E1*6 allele in South Africans.
|
15899651 |
2005 |
|
Malignant neoplasm of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We recently characterized the tandem repeat polymorphism in the 5'-flanking region of the human CYP2E1 gene and found that subjects with the homozygous mutant-type (A4/A4) may be at higher risk of developing esophageal cancer.
|
12960506 |
2003 |
|
Malignant neoplasm of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The distribution of genotypes and allele frequencies of the tandem repeats of the 5'-flanking region of the CYP2E1 gene was significantly different in patients with esophageal cancer.
|
12198369 |
2002 |
|
Malignant neoplasm of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have shown in our preliminary study that a genetic polymorphism in cytochrome P450 2E1 (CYP2E1) that is known to activate nitrosamines may be a susceptibility factor involved in the early events leading to the development of esophageal cancer (Lin et al., Cancer Epidemiol.Biomark.Prev., 7: 1013-1018, 1998).
|
10868687 |
2000 |
|
Malignant neoplasm of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that CYP2E1 may be a genetic susceptibility factor involved in the early events leading to the development of esophageal cancer.
|
9829710 |
1998 |
|
Malignant neoplasm of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the genetic polymorphisms of CYP1A1, CYP2E1 and GSTM1 in Japanese esophageal cancer patients (n = 53) with a histological diagnosis of squamous-cell carcinoma, to determine whether susceptibility to esophageal cancer is associated with these polymorphisms.
|
9139841 |
1997 |
|
Malignant neoplasm of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rsal and Dral polymorphisms of CYP2E1 and Mspl polymorphism of CYP1A1 were studied in 260 controls and 511 alcoholic patients, without any clinical symptoms (n = 202) or with various ethanol-related diseases (n = 309), such as liver cirrhosis (n = 110), esophageal cancer (n = 62), upper aerodigestive tract cancer (n = 96), and other miscellaneous diseases (n = 41).
|
8892524 |
1996 |