Alcohol abuse
|
0.740 |
Biomarker
|
disease |
RGD |
CYP2E1 testis expression and alcohol-mediated changes of rat spermatogenesis indices and type I collagen.
|
23819932 |
2013 |
Alcohol abuse
|
0.740 |
Biomarker
|
disease |
PSYGENET |
CYP2E1 gene promoter polymorphism -1293G>C increases the risk of essential hypertension in men with alcohol abuse.
|
24288753 |
2013 |
Alcohol abuse
|
0.740 |
Biomarker
|
disease |
CTD_human |
Induction of blood lymphocyte cytochrome P450 2E1 in early stage alcoholic liver cirrhosis.
|
20843640 |
2011 |
Alcohol abuse
|
0.740 |
Biomarker
|
disease |
PSYGENET |
Cytochrome P450 2E1 high activity polymorphism in alcohol abuse and end-organ disease.
|
16425414 |
2005 |
Alcohol abuse
|
0.740 |
AlteredExpression
|
disease |
BEFREE |
Cytochrome P450 2E1 high activity polymorphism in alcohol abuse and end-organ disease.
|
16425414 |
2005 |
Alcohol abuse
|
0.740 |
Biomarker
|
disease |
PSYGENET |
Examination of a CYP2E1 repeat polymorphism in a monkey model of alcohol abuse.
|
11505041 |
2001 |
Alcohol abuse
|
0.740 |
AlteredExpression
|
disease |
BEFREE |
To further investigate autoantibodies against cytochrome P-450s during alcohol abuse, sera of rats chronically treated with ethanol in the total enteral nutrition model and sera from alcoholics with or without alcohol liver disease and from control subjects were analyzed by enzyme-linked immunosorbent assay and Western blotting for the presence of IgG against rat and human CYP2E1, rat CYP3A1, and human CYP3A4.
|
9927612 |
1999 |
Alcohol abuse
|
0.740 |
Biomarker
|
disease |
PSYGENET |
To further investigate autoantibodies against cytochrome P-450s during alcohol abuse, sera of rats chronically treated with ethanol in the total enteral nutrition model and sera from alcoholics with or without alcohol liver disease and from control subjects were analyzed by enzyme-linked immunosorbent assay and Western blotting for the presence of IgG against rat and human CYP2E1, rat CYP3A1, and human CYP3A4.
|
9927612 |
1999 |
Alcohol abuse
|
0.740 |
GeneticVariation
|
disease |
BEFREE |
The findings indicate that Caucasians carrying the Rsa I c2 allele of the CYP2E1 gene may be at higher risk of developing ALD if they abuse alcohol.
|
8747406 |
1995 |
Alcohol abuse
|
0.740 |
Biomarker
|
disease |
PSYGENET |
The findings indicate that Caucasians carrying the Rsa I c2 allele of the CYP2E1 gene may be at higher risk of developing ALD if they abuse alcohol.
|
8747406 |
1995 |
Alcohol abuse
|
0.740 |
AlteredExpression
|
disease |
BEFREE |
CYP2E1 expression was not detected in fetal liver, kidney, lung, placenta (18 weeks gestational age) or liver (6 weeks gestational age) obtained at termination of pregnancy where maternal alcohol abuse had been established.
|
1575782 |
1992 |
Alcoholic Intoxication, Chronic
|
0.600 |
Biomarker
|
disease |
BEFREE |
By comparing the differences of genotype, allele, and pertinent haplotype frequencies, we did not support a genetic association between CYP2E1 and AD in Han Taiwanese either by single allele tests or haplotype-based analyses.
|
29588096 |
2018 |
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that the CAT c.-262C>T genetic polymorphism influences the susceptibility to alcohol dependence and severity of alcohol dependence, while CYP2E1 c.-1053C>T polymorphism influences the expression of obsessive-compulsive and anxiety symptoms.
|
25514903 |
2015 |
Alcoholic Intoxication, Chronic
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Our findings suggest that the CAT c.-262C>T genetic polymorphism influences the susceptibility to alcohol dependence and severity of alcohol dependence, while CYP2E1 c.-1053C>T polymorphism influences the expression of obsessive-compulsive and anxiety symptoms.
|
25514903 |
2015 |
Alcoholic Intoxication, Chronic
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Two pathological states characterized by CYP2E1 induction were simulated on Wistar male rats: experimental alcoholism and type I diabetes.
|
25323755 |
2014 |
Alcoholic Intoxication, Chronic
|
0.600 |
Biomarker
|
disease |
PSYGENET |
We investigated whether variation in genes encoding cytochrome P450 2E1 (CYP2E1) or acetaldehyde-metabolising enzymes (ALDH1A1, ALDH2) might alter the risk of AD, with and without symptoms of anxiety, in a Cape population with mixed ancestry.
|
24567230 |
2014 |
Alcoholic Intoxication, Chronic
|
0.600 |
Biomarker
|
disease |
PSYGENET |
First, with the Principle Component analysis, six proteins, CYP2E1, FAM25, CA3, BHMT, HIBADH and ECHS1, involved in oxidation reduction, energy and lipid metabolism and amino acid metabolism, were identified as the most differentially expressed gene products across all of the experimental conditions of our chronic alcoholism model.
|
24658151 |
2014 |
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether variation in genes encoding cytochrome P450 2E1 (CYP2E1) or acetaldehyde-metabolising enzymes (ALDH1A1, ALDH2) might alter the risk of AD, with and without symptoms of anxiety, in a Cape population with mixed ancestry.
|
24567230 |
2014 |
Alcoholic Intoxication, Chronic
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, genes related to alcohol addiction, such as dopamine receptor D2 in the brain, or liver alcohol-metabolizing enzymes, such as alcohol dehydrogenase class I polypeptide B, cytochrome P450 2E1 and aldehyde dehydrogenase class 2, may vary from one individual to another.
|
24307790 |
2013 |
Alcoholic Intoxication, Chronic
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Thus, genes related to alcohol addiction, such as dopamine receptor D2 in the brain, or liver alcohol-metabolizing enzymes, such as alcohol dehydrogenase class I polypeptide B, cytochrome P450 2E1 and aldehyde dehydrogenase class 2, may vary from one individual to another.
|
24307790 |
2013 |
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Combined linkage and association indicate that sequence changes in or near CYP2E1 affect the level of response to alcohol providing a predictor of risk of alcoholism.
|
20958328 |
2011 |
Alcoholic Intoxication, Chronic
|
0.600 |
Biomarker
|
disease |
CTD_human |
Induction of blood lymphocyte cytochrome P450 2E1 in early stage alcoholic liver cirrhosis.
|
20843640 |
2011 |
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No significant associations between the 4 polymorphisms of CYP2E1 and alcoholism were revealed by single allele tests.
|
18034693 |
2007 |
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This documents the presence of a polymorphism of CYP2E1 that is overexpressed in alcoholic Otomies, in which the variant allele (A1 of CYP2E1/TaqI) is associated with increased susceptibility to alcoholism.
|
17134659 |
2006 |
Alcoholic Intoxication, Chronic
|
0.600 |
Biomarker
|
disease |
BEFREE |
Hepatic microsomal cytochrome P450 (CYP2E1), induced in chronic alcohol abuse, is also reported to oxidize ethanol.
|
16806343 |
2006 |