Craniofacial Abnormalities
|
0.300 |
Biomarker
|
group |
CTD_human |
Characterization of human short chain dehydrogenase/reductase SDR16C family members related to retinol dehydrogenase 10.
|
27793605 |
2017 |
Fetal Mummification
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Characterization of human short chain dehydrogenase/reductase SDR16C family members related to retinol dehydrogenase 10.
|
27793605 |
2017 |
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
|
30578418 |
2019 |
Glioma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Reverse transcription-polymerase chain reaction (RT-PCR) was used to determine the expression levels of RDH10 in healthy glial cells and glioma cells.
|
31613821 |
2019 |
Glioma
|
0.020 |
Biomarker
|
disease |
BEFREE |
This suggests that RDH10 promotes glioma cell proliferation and survival by regulating the TWEAK-NF-κB axis, and that it could potentially serve as a novel target for human glioma treatment.
|
29285249 |
2017 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
RDH10 knockdown might inhibit metastasis of glioma cells via the TGF-β/SMAD signaling pathway.
|
31613821 |
2019 |
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Scratch and transwell assays were used to assess cell migration and invasion after RDH10 knockdown.
|
31613821 |
2019 |
Choanal Atresia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings demonstrate that RDH10 is essential during the early stages of facial morphogenesis for the formation of a functional nasal airway, and furthermore establish Rdh10 mutant mice as an important model system to study CA.
|
28169399 |
2017 |
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here, we show that RDH10 is highly expressed in human gliomas, and its expression correlates with tumor grade and patient survival times.
|
29285249 |
2017 |
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Expression of RALDH2 and RDH10 was conserved in 100 % of adenomas and in 90 and 98 %, respectively, of carcinomas, whereas staining for CRBP1 was decreased in 9 % of FAs and 28 % of carcinomas, mainly anaplastic carcinomas (55 %).
|
23639973 |
2013 |
Thyroid Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We characterized the expression of RA receptors and retinoid X receptors (RARs and RXRs) in a series of 111 thyroid tumors and investigated the mechanisms responsible for their deregulation: hypermethylation of the RARB2 promoter, loss of heterozygosity (LOH) in the regions of RARB and RXRA, and altered expression of CRBP1 and enzymes involved in RA biosynthesis (RDH10 and RALDH2).
|
23639973 |
2013 |
Anaplastic carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of RALDH2 and RDH10 was conserved in 100 % of adenomas and in 90 and 98 %, respectively, of carcinomas, whereas staining for CRBP1 was decreased in 9 % of FAs and 28 % of carcinomas, mainly anaplastic carcinomas (55 %).
|
23639973 |
2013 |
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Contrary to this CYP4Z1, KIR and RDH10 were prevalently mutated in tumors of grade 3, stage III suggesting that they could play a role in NSCLC progression.
|
19473719 |
2010 |
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These results indicated that forced expression of RDH10 produces antiproliferative effects highly comparable to those achieved by retinoids treatment and thus the development of a gene therapy, finalized at the restoration of the enzymatic and receptorial machinery of the RA pathway, could be a possible curative strategy for hepatocellular carcinoma (HCC).
|
17218779 |
2007 |
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
These results indicated that forced expression of RDH10 produces antiproliferative effects highly comparable to those achieved by retinoids treatment and thus the development of a gene therapy, finalized at the restoration of the enzymatic and receptorial machinery of the RA pathway, could be a possible curative strategy for hepatocellular carcinoma (HCC).
|
17218779 |
2007 |