Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
α-Synuclein (ASN) and parkin, a multifunctional E3 ubiquitin ligase, are two proteins that are associated with the pathophysiology of Parkinson's disease (PD).
|
29681024 |
2019 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the E3 ubiquitin ligase parkin are the most common known cause of autosomal recessive Parkinson's disease (PD), and parkin depletion may play a role in sporadic PD.
|
31406131 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dysregulation of mitophagy, whereby damaged mitochondria are labeled for degradation by the mitochondrial kinase PINK1 and E3 ubiquitin ligase Parkin with phosphorylated ubiquitin chains (p-S65 ubiquitin), may contribute to neurodegeneration in Parkinson's disease.
|
31801089 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we found that a E3 ubiquitin ligase Peli1 is dramatically induced only in the substantia nigra (SN) of the human and mouse PD brains.
|
31142803 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Parkin is an E3 ubiquitin ligase involved in Parkinson's disease (PD).
|
30074231 |
2019 |
Parkinson Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ring finger protein 146 (RNF146) is an E3 ubiquitin ligase whose activity prevents poly (ADP-ribose) polymerase 1 (PARP1)-dependent neurodegeneration in Parkinson's disease (PD).
|
30974833 |
2019 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Parkinson's disease (PD)-associated E3 ubiquitin ligase Parkin is enriched at glutamatergic synapses, where it ubiquitinates multiple substrates, suggesting that its mutation/loss-of-function could contribute to the etiology of PD by disrupting excitatory neurotransmission.
|
30200940 |
2018 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Parkin encodes an E3 ubiquitin ligase, and mutations affecting its catalytic potential are implicated in autosomal recessive Parkinson's disease (PD).
|
29223129 |
2018 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Parkin, an E3 ubiquitin ligase and a Parkinson's disease (PD) related gene, translocates to impaired mitochondria and drives their elimination via autophagy, a process known as mitophagy.
|
30219582 |
2018 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Parkin functions as a multipurpose E3 ubiquitin ligase, and Parkin loss of function is associated with both sporadic and familial Parkinson's disease (PD).
|
29987020 |
2018 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Parkin (PARK2) is an E3 ubiquitin ligase that is commonly mutated in Familial Parkinson's Disease (PD).
|
28399880 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Parkin, a tumor suppressor and Parkinson's disease (PD) associated gene, is an E3 ubiquitin ligase crucial for mitophagy.
|
27148961 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mitochondrial kinase PTEN-induced putative kinase 1 (PINK1) and E3 ubiquitin ligase Parkin function in a common pathway to regulate mitochondrial homeostasis contributing to the pathogenesis of Parkinson disease.
|
28778978 |
2017 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in E3 ubiquitin ligase Parkin have been linked to familial Parkinson's disease.
|
29180628 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The identifications of mutations in genes encoding PINK1 (PTEN-induced kinase 1) and Parkin (E3 ubiquitin ligase) in familial PD and their functional association with mitochondrial quality control provided further support to this hypothesis.
|
27911343 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Parkin is an E3 ubiquitin ligase originally characterized in the pathogenesis of Parkinson disease; however, its potential role in acute inflammatory processes and lung EC function remains largely unknown.
|
27693468 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
PARK2 encodes for the E3 ubiquitin ligase parkin and is implicated in the development of Parkinson's disease (PD).
|
28656059 |
2017 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Parkin (which encoded by Park2), an E3 ubiquitin ligase, is the most frequently mutated gene that has casually been linked to autosomal recessive early onset familial PD.
|
28086194 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Parkin, an E3 ubiquitin ligase, has been studied extensively in all major protein misfolding aggregating diseases, especially Parkinson's disease and Alzheimer's disease, but the role of parkin in TSEs remains unknown.
|
27430567 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Parkinson's disease (PD)-related protein F-box only protein 7 (Fbxo7) is the substrate-recognition component of the Skp1-Cullin-F-box protein E3 ubiquitin ligase complex.
|
27689878 |
2017 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Parkin, an E3 ubiquitin ligase, is the most frequently mutated gene in hereditary Parkinson's disease.
|
29138676 |
2017 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Parkin, an E3 ubiquitin ligase, is the most frequently mutated gene in hereditary Parkinson's disease.
|
28169962 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings provide a molecular mechanism of how Parkin recruitment to the mitochondria and Parkin activation as an E3 ubiquitin ligase are regulated by PINK1 and explain the previously unknown mechanism of how Parkin mutations in the UBL domain cause PD pathogenesis.
|
26631732 |
2016 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Parkinson's Disease (PD) related genes PINK1, a protein kinase [1], and Parkin, an E3 ubiquitin ligase [2], operate within the same pathway [3-5], which controls, via specific elimination of dysfunctional mitochondria, the quality of the organelle network [6].
|
26517048 |
2016 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the genes encoding the mitochondrial kinase PINK1 and the E3 ubiquitin ligase Parkin cause autosomal recessive Parkinson's disease (PD).
|
27251035 |
2016 |