|
Choriocarcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
More specifically, serotonin (5-HT) regulates the estrogen biosynthetic enzyme aromatase (cytochrome P450 19; CYP19), which is disrupted by fluoxetine and its active metabolite norfluoxetine in BeWo choriocarcinoma cells.
|
31509772 |
2019 |
|
Choriocarcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we sought to investigate the role of microRNA, let-7g, in posttranscriptional regulation of aromatase in human trophoblast choriocarcinoma cell line, JEG3.
|
30216511 |
2018 |
|
Choriocarcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The inhibitory effects of the standardized extracts of Ginkgo biloba on Aromatase activity in JEG-3 human choriocarcinoma cells.
|
23339036 |
2013 |
|
Choriocarcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, exposure of the H295R cells to isoflavonoids caused a decrease in testosterone production, and various mixtures of PEs significantly stimulated MCF-7 human breast adenocarcinoma cell growth and induced aromatase activity in JEG-3 choriocarcinoma cells.
|
20043267 |
2010 |
|
Choriocarcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we have screened 30 selected pesticides with known, unknown or supposed effects on aromatase activity, for their ability to modulate aromatase activity in the human choriocarcinoma JEG-3 cell line after both short (2 h) and long exposure (24 h).
|
16996190 |
2006 |
|
Choriocarcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we investigated the effects of trialkyltin compounds, which are suspected endocrine disrupters, on aromatase activity and hCG secretion in human choriocarcinoma JAR, JEG-3, and BeWo cells.
|
12050258 |
2002 |
|
Choriocarcinoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
To evaluate the effect of 17alpha-methyl testosterone on the expression and activity of aromatase, we tested the choriocarcinoma Jar cell line, a cell line that express high levels of P450 aromatase, and the macrophage-like THP-1 cells, which express aromatase only after undergoing differentiation.
|
11850230 |
2001 |
|
Choriocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several flavonoids such as 7-hydroxyflavone and chrysin (5,7-dihydroxyflavone) were shown to inhibit the formation of 3H-17beta-estradiol from 3H-androstenedione (IC(50)<1.0 microM) in human choriocarcinoma JEG-3 cells and in human embryonic kidney cells HEK 293 transfected with human aromatase gene (Arom+HEK 293).
|
11595503 |
2001 |
|
Choriocarcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To evaluate the effect of 17alpha-methyl testosterone on the expression and activity of aromatase, we tested the choriocarcinoma Jar cell line, a cell line that express high levels of P450 aromatase, and the macrophage-like THP-1 cells, which express aromatase only after undergoing differentiation.
|
11850230 |
2001 |
|
Choriocarcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
These results suggest that the imperfect palindromic sequence upstream of exon I.1 plays an important but novel role in the regulated expression of the CYP19 gene in choriocarcinoma cells.
|
9528950 |
1998 |
|
Choriocarcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We now report that ICI 182,780 is also an inhibitor of aromatase activity in fibroblasts isolated from the normal human breast as well as other carcinoma cell lines that express aromatase (MCF-7Ca breast cancer and JEG-3 choriocarcinoma).
|
9883986 |
1998 |
|
Choriocarcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recently, we have localized a transcriptional activating element at positions -2141 to -2115 relative to the major cap site of the gene, by transient expression analyses in human BeWo choriocarcinoma cells using the bacterial chloramphenicol acetytransferase reporter gene ligated with CYP19 promoter sequences which regulate expression in this tissue.
|
7635140 |
1995 |
|
Choriocarcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
An antisense oligodeoxynucleotide complementary to the translation start region of human aromatase transcripts (antisense-arom) was synthesized and used to inhibit cyclic AMP-triggered aromatase gene expression in a human choriocarcinoma cell line (JEG-3), both as occurring in an autocrine fashion by secreted human chorionic gonadotropin or as induced by application of the membrane-permeating dibutyryl cyclic AMP.
|
8069860 |
1994 |
|
Choriocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied the effects of cholera toxin (CT), an activator of adenylate cyclase, and 12-O-tetradecanoyl phorbol 13-acetate (TPA), a phorbol ester protein kinase C activator, on the levels of messenger (m) RNAs encoding aromatase cytochome P-450 (P-450AROM) and 17 beta-HSD in cultured JEG-3 choriocarcinoma cells.
|
1309352 |
1992 |