|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aromatase is most widely known for its roles in reproduction and reproductive system diseases, and as a target for inhibitor therapy in estrogen-sensitive diseases including cancer, endometriosis, and leiomyoma (141, 143).
|
27252161 |
2016 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The protein expression of ERα, ERβ and aromatase was similar in leiomyoma and normal myometrium (p = 0.239, p = 0.695 and p = 0.203, respectively).
|
22377971 |
2012 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analysis of leiomyoma tissue for biomarkers may predict the response to hormonal treatments such as aromatase inhibitors.
|
19240151 |
2009 |
|
Fibroid Tumor
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Polymorphisms of CYP17A1, CYP19, and androgen in Brazilian women with uterine leiomyomas.
|
18601603 |
2008 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In smooth muscle cells isolated from leiomyoma (LSMCs), dibutyryl cAMP significantly induced aromatase mRNA and enzyme activity.
|
18182446 |
2008 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
In smooth muscle cells isolated from leiomyoma (LSMCs), dibutyryl cAMP significantly induced aromatase mRNA and enzyme activity.
|
18182446 |
2008 |
|
Fibroid Tumor
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The primary in vivo aromatase promoter in leiomyoma tissues in non-Asian U.S. women is the prostaglandin E(2)/cAMP-responsive I.3/II region.
|
17341559 |
2007 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Aromatase P450 expression in the human endometrium is thought to be restricted to women with proliferative reproductive tract disorders such as endometriosis, leiomyomas and adenomyosis.
|
14747179 |
2004 |
|
Fibroid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Certain doses of competitive aromatase inhibitors would completely inhibit estrogen production in leiomyoma, whereas ovarian production of estrogen would continue at reduced levels.
|
15083381 |
2004 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, estrogen metabolism, including the expression pattern of aromatase and the regulation of 17 beta-hydroxysteroid dehydrogenase type 2 (an enzyme responsible for the inactivation of estradiol to estrone), is altered in the eutopic endometrium of women with endometriosis, adenomyosis, and/or leiomyomas compared to that in the eutopic endometrium of women without disease.
|
12650711 |
2002 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Among 21 leiomyomas, I.4-specific transcript and PII-specific transcript were predominant in 18 and 2 leiomyomas, respectively, whereas the remaining leiomyoma was negative for aromatase P450 expression.
|
12050211 |
2002 |
|
Fibroid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In leiomyoma smooth muscle cells in culture (n = 4) and tissue explants (n = 4), aromatase activity was stimulated by dibutyryl cAMP, and this effect was potentiated by a phorbol ester.
|
8126151 |
1994 |