NKX2-3, NK2 homeobox 3, 159296

N. diseases: 22; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE By contrast, variation in the gene encoding the interleukin-23 (IL-23) receptor subunit, as well as in the IL12B, STAT3 and NKX2-3 gene regions, is associated with both Crohn's disease and ulcerative colitis. 18500230 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection. 18438405 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE We found 14 SNPs tagging 9 loci, including 21q21.1, NKX2-3, MST1, the HLA region, 1p36.13, IL10, JAK2, ORMDL3, and IL23R, to be associated with UC. 23974994 2013
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE We confirmed the association of SNP rs10883365 located in the 5' flanking region of NKX2-3 with Japanese UC and colonic CD and determined the risk haplotype (haplotype B) for UC. 21514341 2011
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE Consistent with epidemiologic predictions, many IBD-associated loci demonstrate genome-wide significant associations to both CD and UC, notably, genes whose products function in the interleukin-23 pathway, and transcription factors, including NK2 transcription factor related, locus 3 (NKX2-3), SMAD3, STAT3, ZMIZ1, and c-REL. 21530736 2011
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease LHGDN Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection. 18438405 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE To generate large-scale evidence on whether NKX2-3 polymorphisms are associated with CD or UC susceptibility we have conducted a meta-analysis of 17 studies involving 17329 patients and 18029 controls. 24473197 2014
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE NKX2-3 rs10883365 variant allele was associated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79). 21049557 2010
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE We confirmed that the NKX2-3 polymorphism is associated with common susceptibility to IBD and that HLA-DRB1*0450 alleles increase susceptibility to CD but reduce risk for UC while HLA-DRB1*1502 alleles increase susceptibility to UC but reduce CD risk. 23942620 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 GeneticVariation disease BEFREE To generate large-scale evidence on whether NKX2-3 polymorphisms are associated with CD or UC susceptibility we have conducted a meta-analysis of 17 studies involving 17329 patients and 18029 controls. 24473197 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 GeneticVariation disease BEFREE We confirmed that the NKX2-3 polymorphism is associated with common susceptibility to IBD and that HLA-DRB1*0450 alleles increase susceptibility to CD but reduce risk for UC while HLA-DRB1*1502 alleles increase susceptibility to UC but reduce CD risk. 23942620 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 GeneticVariation disease BEFREE NKX2-3 rs10883365 variant allele was associated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79). 21049557 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 GeneticVariation disease BEFREE By contrast, variation in the gene encoding the interleukin-23 (IL-23) receptor subunit, as well as in the IL12B, STAT3 and NKX2-3 gene regions, is associated with both Crohn's disease and ulcerative colitis. 18500230 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 GeneticVariation disease BEFREE In the pediatric cohort the associations of TNFSF15, NKX2-3 with CD, and PTGER4, NKX2-3, ZNF365, IFNG, PSMG1 with UC, were confirmed. 21818367 2011
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 GeneticVariation disease BEFREE Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients. 18936107 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 GeneticVariation disease LHGDN Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 GeneticVariation disease BEFREE SNPs rs72553867 (IRGM gene), rs4409764 (NKX2-3 gene), and rs3731772 (AOX1 gene) increase the risk of pCD. 31844038 2019
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 GeneticVariation disease BEFREE In conclusion, no evidence of association with CD has been reported for the Crohn's disease susceptibility polymorphisms studied in the NKX2-3, ATG16L1, and IRGM genes. 19683022 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 GeneticVariation disease BEFREE We confirmed the association of SNP rs10883365 located in the 5' flanking region of NKX2-3 with Japanese UC and colonic CD and determined the risk haplotype (haplotype B) for UC. 21514341 2011
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 GeneticVariation disease BEFREE We confirmed 6 previously reported loci in Caucasian: GPR35 at 2q37 (rs3749172; P = 5.30 × 10, odds ratio [OR] = 1.45), ZNF365 at 10q21 (rs224143; P = 2.20 × 10, OR = 1.38), ZMIZ1 at 10q22 (rs1250569; P = 3.05 × 10, OR = 1.30), NKX2-3 at 10q24 (rs4409764; P = 7.93 × 10, OR = 1.32), PTPN2 at 18p11 (rs514000; P = 9.00 × 10, OR = 1.33), and USP25 at 21q11 (rs2823256; P = 2.49 × 10, OR = 1.35), bringing the number of known CD loci (including 3 in the HLA) in Koreans to 15. 25489960 2015
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.090 GeneticVariation group BEFREE We speculate that the rs11190140 may regulate NKX2-3 expression and have a role in IBD pathogenesis. 21803625 2012
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.090 GeneticVariation group BEFREE Contribution of NKX2-3 polymorphisms to inflammatory bowel diseases: a meta-analysis of 35358 subjects. 24473197 2014
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.090 GeneticVariation group BEFREE NKX2-3 and IRGM are susceptibility loci for IBD in Eastern European patients. 21049557 2010
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.090 GeneticVariation group BEFREE Consistent with epidemiologic predictions, many IBD-associated loci demonstrate genome-wide significant associations to both CD and UC, notably, genes whose products function in the interleukin-23 pathway, and transcription factors, including NK2 transcription factor related, locus 3 (NKX2-3), SMAD3, STAT3, ZMIZ1, and c-REL. 21530736 2011
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.090 GeneticVariation group BEFREE We confirmed that the NKX2-3 polymorphism is associated with common susceptibility to IBD and that HLA-DRB1*0450 alleles increase susceptibility to CD but reduce risk for UC while HLA-DRB1*1502 alleles increase susceptibility to UC but reduce CD risk. 23942620 2014