Disease: Malignant Neoplasms ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 GeneticVariation group BEFREE Lower <i>CYP27A1</i> was associated with higher risk of lethal cancer in both cohorts, independent of <i>SQLE</i> [adjusted OR for lowest vs. highest quartile of <i>CYP27A1</i>, 2.64; 95% confidence interval (CI), 1.24-5.62]. 30867220 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 Biomarker group BEFREE Our findings suggest that CYP27A1 is a critical cellular cholesterol sensor in prostate cells and that dysregulation of the CYP27A1/27HC axis contributes significantly to prostate cancer pathogenesis.<i>Cancer Res; 77(7); 1662-73.©2017 AACR</i>. 28130224 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 Biomarker group BEFREE Ablation or inhibition of CYP27A1, the enzyme responsible for the rate-limiting step in 27-hydroxycholesterol biosynthesis, significantly reduces metastasis in relevant animal models of cancer. 29021522 2017