|
Non-Small Cell Lung Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Identification of recurrent fusion genes across multiple cancer types.
|
30705370 |
2019 |
|
Glioblastoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Identification of recurrent fusion genes across multiple cancer types.
|
30705370 |
2019 |
|
Giant Cell Glioblastoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Identification of recurrent fusion genes across multiple cancer types.
|
30705370 |
2019 |
|
Glioblastoma Multiforme
|
0.300 |
Biomarker
|
disease |
CTD_human |
Identification of recurrent fusion genes across multiple cancer types.
|
30705370 |
2019 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Coiled-coil domain containing 67 (CCDC67) gene is a tumor suppressor gene that exhibits a significant inhibitory effect on a variety of tumors.
|
31611958 |
2019 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Analysis of the clinicopathological data revealed that the mRNA and protein expression of DEUP1, and its promoter methylation status, was associated with tumor node metastasis stage and tumor differentiation.
|
31423198 |
2019 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Lower CCDC67 expression was significantly associated with aggressive tumor behaviors, such as advanced tumor stages and lymph node metastasis, as well as BRAF mutation.
|
26716505 |
2016 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
We suggest that CCDC67 is a putative tumor suppressor gene that is silenced in gastric cancers by promoter CpG methylation and that it may play an important role in cell signaling and migration related to tumorigenesis.
|
22610074 |
2012 |
|
Papillary thyroid carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
CCDC67 was verified as a target gene of miR-96-5p in PTC.
|
31081096 |
2019 |
|
Papillary thyroid carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The expression of CCDC67, both at mRNA and protein levels, was sharply down-regulated in PTC compared with normal thyroid tissues.
|
26716505 |
2016 |
|
Malignant neoplasm of thyroid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the present study, a thyroid cancer cell line with stable expression of CCDC67 and luciferase reporter genes was generated and identified.
|
31611958 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
Analysis of the clinicopathological data revealed that the mRNA and protein expression of DEUP1, and its promoter methylation status, was associated with tumor node metastasis stage and tumor differentiation.
|
31423198 |
2019 |
|
Thyroid Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the present study, a thyroid cancer cell line with stable expression of CCDC67 and luciferase reporter genes was generated and identified.
|
31611958 |
2019 |
|
Adult Liver Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Taken together, the results of the present study suggested that methylation of the DEUP1 promoter maybe an important mechanism for gene inactivation and has a critical role in the occurrence and development of liver cancer.
|
31423198 |
2019 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Taken together, the results of the present study suggested that methylation of the DEUP1 promoter maybe an important mechanism for gene inactivation and has a critical role in the occurrence and development of liver cancer.
|
31423198 |
2019 |
|
Malignant neoplasm of liver
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Taken together, the results of the present study suggested that methylation of the DEUP1 promoter maybe an important mechanism for gene inactivation and has a critical role in the occurrence and development of liver cancer.
|
31423198 |
2019 |
|
Thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the present study, a thyroid cancer cell line with stable expression of CCDC67 and luciferase reporter genes was generated and identified.
|
31611958 |
2019 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed that the mRNA and protein expression of DEUP1 in adjacent non-tumor tissues was significantly increased compared with in the HCC tissues.
|
31423198 |
2019 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Specifically, we targeted the breakpoints of TMEM135-CCDC67 and MAN2A1-FER fusions in human prostate cancer or hepatocellular carcinoma cells in vitro and in mouse xenografts.
|
28459452 |
2017 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Specifically, we targeted the breakpoints of TMEM135-CCDC67 and MAN2A1-FER fusions in human prostate cancer or hepatocellular carcinoma cells in vitro and in mouse xenografts.
|
28459452 |
2017 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
These results are consistent with CCDC67 being a novel and impaired tumor suppressor gene in PTC, providing important prognostic and therapeutic implications for this cancer.
|
26716505 |
2016 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Lower CCDC67 expression was significantly associated with aggressive tumor behaviors, such as advanced tumor stages and lymph node metastasis, as well as BRAF mutation.
|
26716505 |
2016 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
These results are consistent with CCDC67 being a novel and impaired tumor suppressor gene in PTC, providing important prognostic and therapeutic implications for this cancer.
|
26716505 |
2016 |
|
Malignant neoplasm of stomach
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Epigenetic alteration of CCDC67 and its tumor suppressor function in gastric cancer.
|
22610074 |
2012 |
|
Carcinogenesis
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
We suggest that CCDC67 is a putative tumor suppressor gene that is silenced in gastric cancers by promoter CpG methylation and that it may play an important role in cell signaling and migration related to tumorigenesis.
|
22610074 |
2012 |