DisGeNET - a database of gene-disease associations

DACH1, dachshund family transcription factor 1, 1602

N. diseases: 74; N. variants: 12

Disease: Malignant neoplasm of colon and/or rectum ×

Source: ALL

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Disease

Score _gda

Association Type

Type

Original DB

Sentence supporting the association

PMID

PMID Year

CUI:	C4722085
Disease:	Malignant neoplasm of colon and/or rectum

Malignant neoplasm of colon and/or rectum

0.030

Biomarker

disease

BEFREE

MicroRNA-552 promotes tumor cell proliferation and migration by directly targeting DACH1 via the Wnt/β-catenin signaling pathway in colorectal cancer.

28927149

2017

CUI:	C4722085
Disease:	Malignant neoplasm of colon and/or rectum

Malignant neoplasm of colon and/or rectum

0.030

PosttranslationalModification

disease

BEFREE

DACH1 is frequently methylated in hepatic and colorectal cancer.

24912879

2014

CUI:	C4722085
Disease:	Malignant neoplasm of colon and/or rectum

Malignant neoplasm of colon and/or rectum

0.030

Biomarker

disease

BEFREE

Epigenetic regulation of DACH1, a novel Wnt signaling component in colorectal cancer.

24149323

2013